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dc.contributor.authorMäkelä, J.T.A
dc.contributor.authorHan, S-K
dc.contributor.authorHerzog, W
dc.contributor.authorKorhonen, R.K
dc.date.accessioned2016-06-16T08:59:13Z
dc.date.available2016-06-16T08:59:13Z
dc.date.issued2015-09-18
dc.identifier10.1016/j.jbiomech.2015.06.010
dc.identifier.citationJ.T.A Mäkelä, S-K Han, W Herzog, R.K Korhonen, Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage, Journal of Biomechanics, Volume 48, Issue 12, 18 September 2015, Pages 3369-3376, ISSN 0021-9290, http://dx.doi.org/10.1016/j.jbiomech.2015.06.010. (http://www.sciencedirect.com/science/article/pii/S0021929015003474) Keywords: Articular cartilage; Osteoarthritis; Anterior cruciate ligament transection; Knee joint; Finite element analysisfi_FI
dc.identifier.issn0021-9290
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/94
dc.descriptionArticle
dc.description.abstractIn this study, fibril-reinforced poroelastic (FRPE) modeling was used for rabbit knee after anterior cruciate ligament transection (ACLT) to assess how the mechanical properties of collagen, proteoglycans, and fluid in articular cartilage change in early osteoarthritis, and how site-specific these changes are. Unilateral ACLT was performed in eight skeletally mature, female New Zealand white rabbits. A separate control (CTRL) group consisted of knee joints of five non-operated rabbits. Animals were sacrificed at four weeks after ACLT and cartilage-on-bone samples from femoral groove, medial and lateral femoral condyles, and tibial plateaus were harvested. A stress–relaxation protocol in indentation geometry was applied and the FRPE model was fitted to the experimental force–time curve by minimizing the mean absolute error between experiment and simulation. The optimized parameters were: fibril network modulus (Ef), representing the collagen network; non-fibrillar matrix modulus (Enf), representing the PG matrix; and permeability (k), representing fluid flow. Permeability was increased significantly in the ACLT group compared to the CTRL group knees at all sites except for the medial tibial plateau. ACLT also caused a decrease in the Ef at all sites except for the medial and lateral tibial plateaus. The Enf of the ACLT group knees was altered only for the lateral femoral condyle. The results of this study suggest that early osteoarthritis primarily affects cartilage permeability and impairs the collagen network stiffness in a site-specific manner. These findings from early osteoarthritis indicate that fluid flow velocity in articular cartilage may change prior to quantifiable structural alterations in the tissue.fi_FI
dc.language.isoenfi_FI
dc.publisherElsevier BVfi_FI
dc.relation.ispartofseriesJournal of Biomechanics
dc.relation.urihttp://dx.doi.org/10.1016/j.jbiomech.2015.06.010
dc.rightsAll rights reserved
dc.subjectArticular cartilagefi_FI
dc.subjectOsteoarthritisfi_FI
dc.subjectAnterior cruciate ligament transectionfi_FI
dc.subjectKnee jointfi_FI
dc.subjectFinite element analysisfi_FI
dc.titleVery early osteoarthritis changes sensitively fluid flow properties of articular cartilagefi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionFinal Draft
dc.contributor.departmentFaculty of Science and Forestry
uef.solecris.id35189258
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Elsevier Ltd
dc.relation.doi10.1016/j.jbiomech.2015.06.010
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange3369–3376
dc.relation.issn0021-9290
dc.relation.issue12
dc.relation.volume48
dc.rights.accesslevelopenAccess


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