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dc.contributor.authorCarlberg, Carsten
dc.contributor.authorMolnár, Ferdinand
dc.date.accessioned2016-06-20T07:41:15Z
dc.date.available2016-06-20T07:41:15Z
dc.date.issued2015-01-21
dc.identifier10.1139/cjpp-2014-0383
dc.identifier.citationCarlberg, Carsten, Molnár, Ferdinand 2015. Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view 1. Canadian Journal of Physiology and Pharmacology Vol.: 93 Issue: 5. Doi: 10.1139/cjpp-2014-0383. Issn: 0008-4212.fi_FI
dc.identifier.issn0008-4212
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/97
dc.descriptionArticle
dc.description.abstractVitamin D3 is one of the few natural compounds that has, via its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation. For efficiently applying the therapeutic and disease-preventing potential of 1,25(OH)2D3 and its synthetic analogs, the key steps in vitamin D signaling need to be understood. These are the different types of molecular interactions with the VDR, such as (i) the complex formation of VDR with genomic DNA, (ii) the interaction of VDR with its partner transcription factors, (iii) the binding of 1,25(OH)2D3 or its synthetic analogs within the ligand-binding pocket of the VDR, and (iv) the resulting conformational change on the surface of the VDR leading to a change of the protein–protein interaction profile of the receptor with other proteins. This review will present the latest genome-wide insight into vitamin D signaling, and will discuss its therapeutic implications.fi_FI
dc.language.isoenfi_FI
dc.publisherCanadian Science Publishingfi_FI
dc.relation.ispartofseriesCanadian Journal of Physiology and Pharmacology
dc.relation.urihttp://dx.doi.org/10.1139/cjpp-2014-0383
dc.rightsAll rights reserved
dc.subjectvitamin Dfi_FI
dc.subjectvitamin D analogsfi_FI
dc.subjectchromatin immunoprecipitationfi_FI
dc.subjectcrystal structurefi_FI
dc.subjectVDR partner proteinsfi_FI
dc.subjectvitamin D signaling in vivofi_FI
dc.titleVitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view 1fi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionFinal Draft
dc.contributor.departmentFaculty of Health Sciences
uef.solecris.id32304940
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© NRC Research Press or its licensors
dc.relation.doi10.1139/cjpp-2014-0383
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.relation.issn0008-4212
dc.relation.issue5
dc.relation.volume93
dc.rights.accesslevelopenAccess


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