Browsing by Subject "Perforin"

Now showing items 1-2 of 2

    • Benzenesulphonamide inhibitors of the cytolytic protein perforin 

      Spicer Julie A; Miller Christian K; O'Connor Patrick D; Jose Jiney; Huttunen Kristiina M; Jaiswal Jagdish K; Denny William A; Akhlaghi Hedieh; Browne Kylie A (Elsevier BV, 2017)
      The pore-forming protein perforin is a key component of mammalian cell-mediated immunity and essential to the pathway that allows elimination of virus-infected and transformed cells. Perforin activity has also been implicated ...
      info:eu-repo/semantics/article

    • Substituted arylsulphonamides as inhibitors of perforin-mediated lysis 

      Spicer JA; Miller CK; O'Connor PD; Jose J; Huttunen KM; Jaiswal JK; Denny WA; Akhlaghi H; Browne KA; Trapani JA (Elsevier BV, 2017)
      The structure-activity relationships for a series of arylsulphonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however inappropriate ...
      info:eu-repo/semantics/article