Browsing Terveystieteiden tiedekunta by Departments "A.I. Virtanen -instituutti"
Now showing items 1-20 of 240
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3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
(Elsevier BV, 2018)Neurodegenerative disorders have an enormous impact on society and healthcare budgets. There has been a high degree of failure in many recent clinical trials for disease-modifying therapeutics. A major factor in this failure ...Tieteelliset aikakauslehtiartikkelit
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5-hydroxytryptamine in migraine: the puzzling role of ionotropic 5-HT3 receptor in the context of established therapeutic effect of metabotropic 5-HT1 subtypes
(Wiley, 2021)5-hydroxytryptamine (5-HT; serotonin) is traditionally considered as a key mediator implicated in migraine. Multiple 5-HT receptor subtypes contribute to a variety of region-specific functional effects. The raphé nuclei ...Tieteelliset aikakauslehtiartikkelit
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A report from the 8th Kuopio Alzheimer Symposium
(Future Medicine Ltd, 2018)The international Kuopio Alzheimer Symposium was organized by the University of Eastern Finland in Kuopio, Finland on June 6–8, 2018 for the 8th time. Approximately 300 researchers in the fields of neuroscience and neurology ...Tieteelliset aikakauslehtiartikkelit
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A web-based application for generating 2D-unfolded cortical maps to analyze the location and extent of cortical lesions following traumatic brain injury in adult rats
(Elsevier BV, 2018)Background Both the type and severity of functional impairments caused by damage to the cerebral cortex depend on the functional cortical areas and networks affected, as well as the lesion extent and type. New method To ...Tieteelliset aikakauslehtiartikkelit
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Activating the Chromatin by Noncoding RNAs
(Mary Ann Liebert Inc, 2017)Significance: The extent and breadth of transcription have recently been uncovered and this has revealed an extensive array of noncoding RNAs (ncRNAs). The biological role and significance of these ncRNAs have been realized ...info:eu-repo/semantics/article
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Acute downregulation of novel hypothalamic protein sushi repeat-containing protein X-Linked 2 (SRPX2) after experimental traumatic brain injury
(Mary Ann Liebert Inc, 2019)Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for ...Tieteelliset aikakauslehtiartikkelit
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Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats
(Mary Ann Liebert Inc, 2019)Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20–30% of patients during the acutephase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers ...Tieteelliset aikakauslehtiartikkelit
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Adenosine promotes endplate nAChR channel activity in adult mouse skeletal muscle fibres via low affinity P1 receptors
(Elsevier BV, 2018)Adenosine is a powerful modulator of skeletal neuromuscular transmission, operating via inhibitory or facilitatory purinergic-type P1 receptors. To date, studies have been focused mainly on the effect of adenosine on ...Tieteelliset aikakauslehtiartikkelit
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Adenoviral gene transfer of Gremlin modulates VEGF-A induced angiogenesis in porcine myocardium
(Mary Ann Liebert Inc, 2020)Coronary artery disease is a major cause of death and disability worldwide. New therapies are needed for patients who do not benefit or are not suitable for current treatments. Angiogenic gene therapy using vascular ...Tieteelliset aikakauslehtiartikkelit
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Adenoviral intramyocardial VEGF-DdeltaNdeltaC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up
(Oxford University Press (OUP), 2017)Aims We evaluated for the first time the effects of angiogenic and lymphangiogenic AdVEGF-DΔNΔC gene therapy in patients with refractory angina. Methods and results Thirty patients were randomized to AdVEGF-DΔNΔC ...info:eu-repo/semantics/article
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Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird
(Wiley, 2018)Secondary sexual trait expression can be influenced by fixed individual factors (such as genetic quality) as well as by dynamic factors (such as age and environmentally induced gene expression) that may be associated with ...Tieteelliset aikakauslehtiartikkelit
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Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
(Frontiers Media SA, 2017)Hydrogen sulfide (H2S) is an endogenously produced neuroactive gas implicated in many key processes in the peripheral and central nervous system. Whereas the neuroprotective role of H2S has been shown in adult brain, the ...info:eu-repo/semantics/article
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Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation
(Elsevier BV, 2017)Type 2 diabetes mellitus (T2DM) is a major risk factor for heart disease. Mortality rates after myocardial infarction (MI)are significantly increased in T2DM patients because of dysfunctional left ventricle (LV). However, ...info:eu-repo/semantics/article
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Alcohol consumption during adolescence is associated with reduced grey matter volumes
(Wiley-Blackwell, 2017)Background and aims Cognitive impairment has been associated with excessive alcohol use, but its neural basis is poorly understood. Chronic excessive alcohol use in adolescence may lead to neuronal loss and volumetric ...Tieteelliset aikakauslehtiartikkelit
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Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy
(Elsevier BV, 2018)Background Labor intensive electroencephalogram (EEG) analysis is a major bottleneck to identifying anti-epileptogenic treatments in experimental models of post-traumatic epilepsy. We aimed to develop an algorithm for ...Tieteelliset aikakauslehtiartikkelit
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Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography
(Springer Nature, 2018)Inflammation plays an important role in the development of atherosclerosis and its complications. Because the folate receptor β (FR-β) is selectively expressed on macrophages, an FR targeted imaging agent could be useful ...Tieteelliset aikakauslehtiartikkelit
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Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
(Springer Nature, 2019)Purpose The study aim was to evaluate the effect of Alzheimer’s disease (AD) and inflammatory insult on the function of L-type amino acid transporter 1 (Lat1) at the mouse blood-brain barrier (BBB) as well as Lat1 function ...Tieteelliset aikakauslehtiartikkelit
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Alzheimerin taudin amyloidikuormaa vähentävät lääkkeet käännekohdassa
(Suomalainen lääkäriseura Duodecim, 2020)Keskeisenä keinona Alzheimerin taudin prosessin pysäyttämiseksi pidetään aivojen amyloidikuorman vähentämistä. Siihen on pyritty immunisaatiolla ja beeta-amyloidi (Aβ) -peptidin muodostumista estävillä pienimolekyylisillä ...Tieteelliset aikakauslehtiartikkelit
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Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers
(Royal Society of Chemistry (RSC), 2020)In this paper we describe a straightforward supramolecular strategy to encapsulate silicon phthalocyanine (SiPc) photosensitizers (PS) in polymeric micelles made of poly(ε-caprolactone)-b-methoxypoly(ethylene glycol) ...Tieteelliset aikakauslehtiartikkelit
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Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture
(Oxford University Press (OUP), 2017)Changes in mature microRNA (miRNA) levels that occur downstream of signaling cascades play an important role during human development and disease. However, the regulation of primary microRNA (pri-miRNA) genes remains to ...info:eu-repo/semantics/article