Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals
Self archived version
final draftDate
2023Author(s)
Heikkinen, Sami
Huber, Nadine
Katisko, Kasper
Kokkola, Tarja
Hartikainen, Päivi
Krüger, Johanna
Leinonen, Ville
Korhonen, Ville E
Herukka, Sanna-Kaisa
Remes, Anne M
Borroni, Barbara
Alberici, Antonella
Libri, Ilenia
Solje, Eino
Haapasalo, Annakaisa
Unique identifier
10.3233/jad-221060Metadata
Show full item recordMore information
Self-archived item
Citation
Heikkinen, Sami. Huber, Nadine. Katisko, Kasper. Kokkola, Tarja. Hartikainen, Päivi. Krüger, Johanna. Leinonen, Ville. Korhonen, Ville E. Herukka, Sanna-Kaisa. Remes, Anne M. Borroni, Barbara. Alberici, Antonella. Libri, Ilenia. Solje, Eino. Haapasalo, Annakaisa. (2023). Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals. Journal of Alzheimer's disease, 93 (2) , 395-401. 10.3233/jad-221060.Rights
© 2023 – IOS Press
Abstract
Frontotemporal dementia (FTD) can manifest as diverse clinical phenotypes and is frequently caused by mutations in different genes, complicating differential diagnosis. This underlines the urgent need for valid biomarkers. Altered lysosomal and immune functions proposedly contribute to FTD pathogenesis. Cathepsins, including cathepsin S, are enzymes preferentially expressed in brain in microglia, which influence lysosomal and immune function. Here, we examined whether alterations in serum cathepsin S levels associate with specific clinical, genetic, or neuropathological FTD subgroups, but no such alterations were observed. However, further research on other lysosomal proteins may reveal new biologically relevant biomarkers in FTD.
Keywords
Link to the original item
https://doi.org/10.3233/JAD-221060Publisher
IOS PressCollections
- Terveystieteiden tiedekunta [1752]