The Identification of a SIRT6 Activator from Brown Algae Fucus distichus
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2017Tekijä(t)
Yksilöllinen tunniste
10.3390/md15060190Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Rahnasto-Rilla Minna K. McLoughlin Padraig. Kulikowicz Tomasz. Doyle Maire. Bohr Vilhelm A. Lahtela-Kakkonen Maija. Ferrucci Luigi. Hayes Maria. Moaddel Ruin. (2017). The Identification of a SIRT6 Activator from Brown Algae Fucus distichus. Marine Drugs, 15 (6) , 190. 10.3390/md15060190.Oikeudet
Tiivistelmä
Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.
Avainsanat
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.3390/md15060190Julkaisija
MDPI AGKokoelmat
- Terveystieteiden tiedekunta [1735]