Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study
Tiedosto(t)
Rinnakkaistallenteen versio
final draftPäivämäärä
2017Tekijä(t)
Yksilöllinen tunniste
10.1016/j.joca.2017.07.002Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Kaukinen P. Podlipská J. Guermazi A. Niinimäki J. Lehenkari P. Roemer FW. Nieminen MT. Koski JM. Saarakkala S. Arokoski JPA. (2017). Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis - the Oulu Knee Osteoarthritis study. OSTEOARTHRITIS AND CARTILAGE, 25 (11) , 1829-1840. 10.1016/j.joca.2017.07.002.Oikeudet
Tiivistelmä
Objective
The main aim was to investigate the associations between Magnetic Resonance Imaging (MRI)-defined structural pathologies of the knee and physical function.
Design
A cohort study with frequency matching on age and sex with eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee osteoarthritis (OA) and 57 asymptomatic subjects was conducted. The subjects underwent knee MRI, and the severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations. WOMAC function subscores were recorded and physical function tests (20-m and 5-min walk, stair ascending and descending, timed up & go and repeated sit-to-stand tests) performed. The association between MRI-defined structural pathologies and physical function tests and WOMAC function subscores were evaluated by linear regression analysis with adjustment for demographic factors, other MRI-features and pain with using effect size (ES) as a measure of the magnitude of an association.
Results
Cartilage degeneration showed significant association with poor physical performance in TUG-, stair ascending and descending-, 20-m- and 5-min walk-tests (ESs in the subjects with cartilage degeneration anywhere between 0.134 [95%CI 0.037–0.238] and 0.224 [0.013–0.335]) and with increased WOMAC function subscore (ES in the subjects with cartilage degeneration anywhere 0.088 [0.012–0.103]). Also, lateral meniscus maceration and extrusion were associated with poor performance in stair ascending test (ESs 0.067 [0.008–0.163] and 0.077 [0.012–0.177]).
Conclusions
After adjustments cartilage degeneration was associated with both decreased self-reported physical function and poor performance in the physical function tests. Furthermore, subjects with lateral meniscus maceration and extrusions showed significantly worse performance in stair ascending tests.
Avainsanat
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1016/j.joca.2017.07.002Julkaisija
Elsevier BVKokoelmat
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