Synthesis of a Biologically Important Adenosine Triphosphate Analogue, ApppD
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2017Tekijä(t)
Turhanen Petri
Yksilöllinen tunniste
10.1021/acsomega.7b00531Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Turhanen Petri. (2017). Synthesis of a Biologically Important Adenosine Triphosphate Analogue, ApppD. ACS Omega, 2 (6) , 2835-2838. 10.1021/acsomega.7b00531.Oikeudet
© 2017 American Chemical Society under the terms of the ACS AuthorChoice License.
Tiivistelmä
The chemical synthesis of a adenosine triphosphate analogue, 1-adenosin-5′-yl 3-(3-methylbut-2-enyl) triphosphoric acid diester (ApppD), is described. ApppD is known to be an active metabolite of the mevalonate pathway in the human body like its structural isomer isopentenyl ester of ATP (ApppI). Very recently, ApppI has been found to possess novel function(s); now it will also be possible to examine the effects of ApppD more precisely because it can be synthesized in reasonable amounts. 1-Adenosin-5′-yl 3-(3-methylbut-2-enyl) diphosphoric acid diester (AppD; a adenosine diphosphate analogue) was also isolated from the synthesis mixture. Both ApppD and AppD were characterized by 1H, 13C, 31P NMR and mass spectrometry methods.