Long-term prognosis of chronic cough : a prospective, observational cohort study
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2017Tekijä(t)
Yksilöllinen tunniste
10.1186/s12890-017-0496-1Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Koskela Heikki O. Lätti Anne M. Purokivi Minna K. (2017). Long-term prognosis of chronic cough : a prospective, observational cohort study. BMC PULMONARY MEDICINE, 17, 146. 10.1186/s12890-017-0496-1.Oikeudet
Tiivistelmä
Background
The long-term prognosis of chronic cough and its determinants need to be clarified.
Methods
This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks’ duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Questionnaire (LCQ), skin prick tests, ambulatory peak expiratory flow monitoring, spirometry before and after 0.4 mgs of salbutamol, exhaled nitric oxide concentration measurement, hypertonic saline cough provocation test, and histamine bronchial provocation test. After five years, a letter was sent to the subjects containing questions about continuation of cough, smoking, indoor exposures, presence of co-morbidities, and current medication. It also contained LCQ and Cough Clinic diagnostic questionnaire. Sixty-eight subjects (76%) responded.
Results
At five years, continuing regular cough was present in 31 (46%) of the subjects and continuing impairment in cough-related quality of life (less than 1.3 points’ improvement in LCQ) in 32 (47%). Continuing regular cough was associated with presence of chronic rhinitis or esophageal reflux disease, baseline mild airway responsiveness to histamine, and baseline strong cough responsiveness to hypertonic saline. Continuing impairment in cough-related quality of life was associated with high body mass index, absence of atopy, absence of pets, and high number of background disorders (esophageal reflux disease, asthma, or chronic rhinitis).
Conclusions
Almost half of subjects with chronic cough suffered of the disorder at five years from initial assessment. Several possible determinants of poor prognosis could be identified.
Avainsanat
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1186/s12890-017-0496-1Julkaisija
Springer NatureKokoelmat
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