Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2017Tekijä(t)
Yksilöllinen tunniste
10.3390/ijms18102056Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Riikonen Raili. (2017). Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18 (10) , 2056. 10.3390/ijms18102056.Oikeudet
Tiivistelmä
Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy–hypsarrhythmia–optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD).
Avainsanat
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.3390/ijms18102056Julkaisija
MDPI AGKokoelmat
- Terveystieteiden tiedekunta [1735]