Long-term exercise protects against cellular stresses in aged mice
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2018Tekijä(t)
Yksilöllinen tunniste
10.1155/2018/2894247Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Belaya, Irina. Suwa, Masataka. Chen, Tao. Giniatullin, Rashid. Kanninen, Katja. Atalay, Mustafa. Kumagai, Shuzo. (2018). Long-term exercise protects against cellular stresses in aged mice. Oxidative Medicine and Cellular Longevity, 2018, 2894247. 10.1155/2018/2894247.Oikeudet
Tiivistelmä
The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice. Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups. The OE group started voluntary wheel-running at 3 months and continued until 24 months of age. Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio—a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles. Notably, GRP78, a key indicator of ER stress, was selectively elevated in T.A. Long-term exercise decreased TxNiP in T.A. and soleus muscles and increased the TRX-1/TxNiP ratio in soleus muscle of aged mice. Inducible HSP70 and constituent HSC70 were upregulated, whereas CHOP was reduced after exercise in soleus muscle. Thus, our data demonstrated that aging induced oxidative stress and activated ER stress-related apoptosis signaling in skeletal muscle, whereas long-term wheel-running improved redox regulation, ER stress adaptation and attenuated ER stress-related apoptosis signaling. These findings suggest that life-long exercise can protect against age-related cellular stress.
Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1155/2018/2894247Julkaisija
Hindawi LimitedKokoelmat
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