Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype
Tiedosto(t)
Rinnakkaistallenteen versio
published versionPäivämäärä
2018Tekijä(t)
Yksilöllinen tunniste
10.1177/1753425918796207Metadata
Näytä kaikki kuvailutiedotLisätietoa
Rinnakkaistallenne
Viittaus
Liukkonen, J. Gürsoy, UK. Könönen, E. Gürsoy, M. Metso, J. Salminen, A. Kopra, E. Jauhiainen, M. Mäntylä, P Buhlin K, Paju S, Sorsa T, Nieminen MS, Lokki ML, Sinisalo J, Pussinen PJ. (2018). Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype. INNATE IMMUNITY, 24 (7) , 439-447. 10.1177/1753425918796207.Oikeudet
Tiivistelmä
Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin-α polymorphisms associate with salivary biomarkers of periodontal disease. A total of 455 individuals with detailed clinical and radiographic periodontal health data were included in the study. A 610 K genotyping chip and a Sequenom platform were used in genotyping analyses. Phospholipid transfer protein activity, concentrations of lymphotoxin-α, IL-8 and myeloperoxidase, and a cumulative risk score (combining Porphyromonas gingivalis, IL-1β and matrix metalloproteinase-8) were examined in saliva samples. Elevated IL-8 and myeloperoxidase concentrations and cumulative risk scores associated with advanced tooth loss, deepened periodontal pockets and signs of periodontal inflammation. In multiple logistic regression models adjusted for periodontal parameters and risk factors, myeloperoxidase concentration (odds ratio (OR); 1.37, P = 0.007) associated with increased odds for having the risk haplotype and lymphotoxin-α concentration with its genetic variants rs2857708, rs2009658 and rs2844482. In conclusion, salivary levels of IL-8, myeloperoxidase and cumulative risk scores associate with periodontal inflammation and tissue destruction, while those of myeloperoxidase and lymphotoxin-α associate with genetic factors as well.
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Linkki alkuperäiseen julkaisuun
http://dx.doi.org/10.1177/1753425918796207Julkaisija
SAGE PublicationsKokoelmat
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