Browsing by Author "A.I. Virtanen -instituutti / Bioteknologia ja molekulaarinen lääketiede"
Now showing items 1-14 of 14
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AdVEGF-B186 and AdVEGF-D(Delta)N(Delta)C induce angiogenesis and increase perfusion in porcine myocardium
(BMJ, 2016)Objective Coronary heart disease remains a significant clinical problem, and new therapies are needed especially for patients with refractory angina for whom the current therapies do not provide sufficient relief. The ...Tieteelliset aikakauslehtiartikkelit
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Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-ĸB cistrome to reprogram the prostate cancer cell transcriptome
(Oxford University Press, 2016)Inflammatory processes and androgen signaling are critical for the growth of prostate cancer (PC), the most common cancer among males in Western countries. To understand the importance of potential interplay between ...info:eu-repo/semantics/article
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Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets
(Nature Publishing Group, 2016)Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers (CRPC) that typically express amplified levels ...info:eu-repo/semantics/article
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Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography
(Mary Ann Liebert Inc, 2016)Cardiac gene transfer for the treatment of ischemic diseases has suffered from low gene transfer efficiency and inability to target treatment genes to the ischemic myocardium. A combined method has been developed based on ...Tieteelliset aikakauslehtiartikkelit
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Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
(Public Library of Science (PLoS), 2016)Platelet-derived growth factors (PDGFs) are key regulators of mesenchymal cells in vertebrate development. To what extent PDGFs also exert beneficial homeostatic or reparative roles in adult organs, as opposed to adverse ...info:eu-repo/semantics/article
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Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases
(, 2017)Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be ...info:eu-repo/semantics/article
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Ocular Phenotype of Mice with Impaired Fibrillin-1 Function on Hypercholesterolemic Apolipoprotein E-Deficient Background
(Gratis Open Access Publishers LLC, 2018)Aim: Transgenic mice with an elastic fiber mutation (C1039G+/-) in the fibrillin-1 gene and apolipoprotein E deficiency express vulnerable atherosclerotic plaque formation in the aorta and coronary and carotid arteries. ...Tieteelliset aikakauslehtiartikkelit
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Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia
(Wiley-Blackwell, 2017)Canonical Wnt/β‐catenin signaling regulates the homeostasis of intestinal epithelium by controlling the balance between intestinal stem cell self‐renewal and differentiation but epigenetic mechanisms enacting the process ...Tieteelliset aikakauslehtiartikkelit
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Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI
(Springer Nature, 2017)Objectives We aimed to investigate whether apparent diffusion coefficients (ADCs) measured by 3.0T diffusion-weighted magnetic resonance imaging (DWI) associate with histological aggressiveness of ovarian cancer (OC) or ...info:eu-repo/semantics/article
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Refractoriness in human atria: Time and voltage dependence of sodium channel availability
(Elsevier BV, 2016)Background Refractoriness of cardiac cells limits maximum frequency of electrical activity and protects the heart from tonic contractions. Short refractory periods support major arrhythmogenic substrates and augmentation ...info:eu-repo/semantics/article
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Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling
(Springer Nature, 2017)Vascular Endothelial Growth Factors (VEGFs) are promising molecules for the treatment of ischemic diseases by pro-angiogenic therapy. Snake venom VEGFs are a novel subgroup with unique receptor binding profiles and as such ...info:eu-repo/semantics/article
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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths
(Oxford University Press (OUP), 2018)Aims Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation within the arterial intima. High plasma concentrations of LDL drive ...Tieteelliset aikakauslehtiartikkelit
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Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules
(Frontiers Media SA, 2018)Endothelial cell (EC) therapy may promote vascular growth or reendothelization in a variety of disease conditions. However, the production of a cell therapy preparation containing differentiated, dividing cells presenting ...Tieteelliset aikakauslehtiartikkelit
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Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart
(Frontiers Media SA, 2017)Vascular endothelial growth factor B (VEGF-B) is a potent mediator of vascular, metabolic, growth, and stress responses in the heart, but the effects on cardiac muscle and cardiomyocyte function are not known. The purpose ...info:eu-repo/semantics/article
