Now showing items 1-2 of 2

    • A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

      Manning A; Highland HM; Gasser J; Sim X; Tukiainen T; Fontanillas P; Grarup N; Rivas MA; Mahajan A; Locke AE; Cingolani P; Pers TH; Viñuela A; Brown AA; Wu Y; Flannick J; Fuchsberger C; Gamazon ER; Gaulton KJ; Im HK; Lakka Timo; Kuulasmaa Teemu; Uusitupa Matti et al. (American Diabetes Association, 2017)
      To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...
      info:eu-repo/semantics/article

    • The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function 

      Chen, Xi; Ayala, Iriscilla; Shannon, Chris; Fourcaudot, Marcel; Acharya, Nikhil K; Jenkinson, Christopher P; Heikkinen, Sami; Norton, Luke (American Diabetes Association, 2018)
      The gene encoding for transcription factor 7-like 2 (TCF7L2) is the strongest type 2 diabetes (T2DM) candidate gene discovered to date. The TCF7L2 protein is a key transcriptional effector of the Wnt/β-catenin signaling ...
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