Browsing by Subject "Type 2 diabetes"
Now showing items 1-6 of 6
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Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver
(Springer Nature, 2017)Background Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the ...info:eu-repo/semantics/article
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
(Springer Nature, 2017)Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to ...info:eu-repo/semantics/article
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Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
(Springer Nature, 2017)Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated ...info:eu-repo/semantics/article
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Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells
(Springer Nature, 2017)Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including ...info:eu-repo/semantics/article
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Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
(Springer Nature, 2017)Background The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish ...info:eu-repo/semantics/article
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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
(Springer Nature, 2017)To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 ...info:eu-repo/semantics/article