Browsing by Subject "epileptogenesis"

Now showing items 1-7 of 7

    • Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats 

      Andrade, Pedro; Banuelos-Cabrera, Ivette; Lapinlampi, Niina; Paananen, Tomi; Ciszek, Robert; Ndode-Ekane, Xavier Ekolle; Pitkanen, Asla (Mary Ann Liebert Inc, 2019)
      Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20–30% of patients during the acutephase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers ...
      Tieteelliset aikakauslehtiartikkelit

    • Algorithm for automatic detection of spontaneous seizures in rats with post-traumatic epilepsy 

      Andrade, Pedro; Paananen, Tomi; Ciszek, Robert; Lapinlampi, Niina; Pitkänen, Asla (Elsevier BV, 2018)
      Background Labor intensive electroencephalogram (EEG) analysis is a major bottleneck to identifying anti-epileptogenic treatments in experimental models of post-traumatic epilepsy. We aimed to develop an algorithm for ...
      Tieteelliset aikakauslehtiartikkelit

    • Big data sharing and analysis to advance research in post-traumatic epilepsy 

      Duncan, Dominique; Vespa, Paul; Pitkanen, Asla; Braimah, Adebayo; Lapinlampi, Niina; Toga, Arthur W (Elsevier BV, 2019)
      We describe the infrastructure and functionality for a centralized preclinical and clinical data repository and analytic platform to support importing heterogeneous multi-modal data, automatically and manually linking data ...
      Tieteelliset aikakauslehtiartikkelit

    • Biomarkers For Epileptogenesis And Its Treatment 

      Engel, Jerome Jr; Pitkänen, Asla (Elsevier BV, 2020)
      There are no pharmacological interventions to prevent the development of epilepsy, although many promising compounds have been identified in the animal laboratory. Clinical trials to validate their effectiveness, however, ...
      Tieteelliset aikakauslehtiartikkelit

    • Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury 

      Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O (Mary Ann Liebert Inc, 2018)
      Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. Given that increased neuronal activity in the brain triggers a blood oxygenation level–dependent (BOLD) response ...
      Tieteelliset aikakauslehtiartikkelit

    • Epilepsy biomarkers - Toward etiology and pathology specificity 

      Pitkänen, Asla; Ekolle, Ndode-Ekane Xavier; Lapinlampi, Niina; Puhakka, Noora (Elsevier BV, 2019)
      A biomarker is a characteristic that is measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities ...
      Tieteelliset aikakauslehtiartikkelit

    • Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers 

      Immonen, Riikka; Harris, Neil G; Wright, David; Johnston, Leigh; Manninen, Eppu; Smith, Gregory; Paydar, Afshin; Branch, Craig; Grohn Olli (Elsevier BV, 2019)
      Posttraumatic epilepsy (PTE) is a major neurodegenerative disease accounting for 20% of symptomatic epilepsy cases. A long latent phase offers a potential window for prophylactic treatment strategies to prevent epilepsy ...
      Tieteelliset aikakauslehtiartikkelit