Browsing by Subject "human"
Now showing items 1-13 of 13
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FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children
(Frontiers Media SA, 2019)The dysfunction of FOXP3-positive regulatory T cells (Tregs) plays a key role in the pathogenesis of autoimmune diseases, including type 1 diabetes (T1D). However, previous studies analyzing the peripheral blood Treg ...Tieteelliset aikakauslehtiartikkelit
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Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membrane
(MDPI AG, 2018)The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet ...Tieteelliset aikakauslehtiartikkelit
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Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism
(Wiley-Blackwell, 2016)Humanin (HN) is a mitochondrially encoded and secreted peptide linked to glucose metabolism and tissue protecting mechanisms. Whether skeletal muscle HN gene or protein expression is influenced by exercise remains unknown. ...Tieteelliset aikakauslehtiartikkelit
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In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species
(Informa UK Limited, 2020)1. Sulfonation is an important high affinity elimination pathway for phenolic compounds. 2. In this study sulfonation of 7-hydroxycoumarin and 13 its derivatives were evaluated in liver cytosols of human and six animal ...Tieteelliset aikakauslehtiartikkelit
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In vivo localised gastrocnemius subtendon representation within the healthy and ruptured human Achilles tendon
(American Physiological Society, 2022)The Achilles tendon (AT) is composed of three distinct in-series elastic subtendons, arising from different muscles in the triceps surae. Independent activation of any of these muscles is thought to induce sliding between ...
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Inflammatory response to dietary linoleic acid depends on FADS1 genotype
(Oxford University Press (OUP), 2019)Background The health benefits of substituting dietary polyunsaturated fatty acids (PUFAs) for saturated fatty acids are well known. However, limited information exists on how the response to dietary intake of linoleic ...Tieteelliset aikakauslehtiartikkelit
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Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study
(Wiley, 2020)Enzymes in the cytochrome P450 family 1 (CYP1) catalyze metabolic activation of procarcinogens and deactivation of certain anticancer drugs. Inhibition of these enzymes is a potential approach for cancer chemoprevention ...Tieteelliset aikakauslehtiartikkelit
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Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion
(Elsevier BV, 2017)Background Adoptive T-cell therapy offers new options for cancer treatment. Clinical results suggest that T-cell persistence, depending on T-cell memory, improves efficacy. The use of interleukin (IL)-2 for in vitro T-cell ...info:eu-repo/semantics/article
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Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration
(IOS Press, 2019)A lot of effort has been done to unravel the genetics underlying early-onset Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). However, many familial early-onset dementia (EOD) cases still show an ...Tieteelliset aikakauslehtiartikkelit
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No evidence of the role of early chemical exposure in the development of ß-cell autoimmunity
(Springer Nature America, Inc, 2018)Exposure to environmental chemicals can modulate the developing immune system, but its role in the pathogenesis of type 1 diabetes is largely unexplored. Our objective was to study the levels of circulating concentrations ...Tieteelliset aikakauslehtiartikkelit
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The effect of intakes of fish and Camelina sativa oil on atherogenic and anti-atherogenic functions of LDL and HDL particles: A randomized controlled trial
(Elsevier BV, 2019)Background and aims Omega-3 fatty acids are known to have several cardioprotective effects. Our aim was to investigate the effects of intakes of fish and Camelina sativa oil (CSO), rich in alpha-linolenic acid, on the ...Tieteelliset aikakauslehtiartikkelit
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The FADS1 Genotype Modifes Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2
(Wiley, 2021)Scope The article investigates the FADS1 rs174550 genotype interaction with dietary intakes of high linoleic acid (LA) and high alpha-linolenic acid (ALA) on the response of fatty acid composition of plasma phospholipids ...Tieteelliset aikakauslehtiartikkelit
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Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells
(Wiley, 2020)Dysfunction of FOXP3‐positive regulatory T cells (Tregs) likely plays a major role in the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). Whether genetic polymorphisms associated with the risk ...Tieteelliset aikakauslehtiartikkelit