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Assessment of induced genomic instability in rat primary astrocytes exposed to intermediate frequency magnetic fields

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Item embargoed until 2021-03-17. Restrictions imposed by the publisher
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final draft
Date
2019
Author(s)
Herrala, M
Naarala, J
Juutilainen, J
Unique identifier
10.1016/j.envres.2019.03.033
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Citation
Herrala, M. Naarala, J. Juutilainen, J. (2019). Assessment of induced genomic instability in rat primary astrocytes exposed to intermediate frequency magnetic fields.  Environmental research, 173, 112-116. 10.1016/j.envres.2019.03.033.
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© Elsevier Inc
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CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

We investigated whether exposure to intermediate frequency magnetic fields (IF MFs) could induce or enhance genomic instability in primary astrocytes. Rat primary astrocytes were exposed to vertical or horizontal 7.5 kHz, 300 μT MF for 24 h. To study possible combined effects with known genotoxic agents, the cells were exposed for 3 h to menadione or methyl methanesulfonate after the MF treatment. Induced genomic instability was evaluated 36 days after exposures using the Comet assay and flow cytometric scoring of micronuclei. Exposure to 7.5 kHz, 300 μT MF did not induce genomic instability alone or in combination with chemicals in measurements performed several cell generations after exposure.

Subjects
intermediate frequency   magnetic fields   micronucleus   comet assay   induced genomic instability   
URI
https://erepo.uef.fi/handle/123456789/7516
Link to the original item
http://dx.doi.org/10.1016/j.envres.2019.03.033
Publisher
Elsevier BV
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  • Luonnontieteiden ja metsätieteiden tiedekunta [1109]
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