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  • Policies and availability of orphan medicines in outpatient care in 24 European countries 

    Sarnola, K; Ahonen, R; Martikainen, JE; Timonen, J (Springer Nature, 2018)
    Purpose To assess pricing and reimbursement policies specific to orphan medicines and the availability and distribution settings of ten recently authorised medicinal products suitable for outpatient care with orphan status ...
  • University students' perceptions of their 'ability selves' and employability: a pilot study 

    Räty, Hannu; Komulainen, Katri; Halvérson, Carita; Nieminen, Anna; Korhonen, Maija (Informa UK LimitedBritannia, 2018)
    This study sets out to investigate the university students’ perceptions of their current and expected ‘ability selves’ and the contribution of such perceptions to students’ views of their own employability. The participants ...
  • Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration 

    Lorenz, MW; Gao, L; Ziegelbauer, K; Norata, GD; Empana, JP; Schmidtmann, I; Lin, HJ; McLachlan, S; Bokemark, L; Ronkainen, K; Amato, M; Schminke, U; Srinivasan, SR; Lind, L; Okazaki, S; Stehouwer, CDA; Willeit, P; Polak, JF; Steinmetz, H; Sander, D; et al (Public Library of Science, 2018)
    Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular ...
  • EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF 

    Groppa, E; Brkic, S; Uccelli, A; Wirth, G; Korpisalo-Pirinen, P; Filippova, M; Dasen. B; Sacchi, V; Muraro, MG; Trani, M; Reginato, S; Gianni-Barrera, R; Ylä-Herttuala, S; Banfi A (EMBO, 2018)
    Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best‐understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative ...
  • Outcomes of Secondary Prevention among Coronary Heart Disease Patients in a High-Risk Region in Finland 

    Repo, T; Tykkyläinen, M; Mustonen, J; Rissanen, TT; Ketonen, M; Toivakka, M; Laatikainen, T (MDPI AG, 2018)
    Despite comprehensive national treatment guidelines, goals for secondary prevention of coronary heart disease (CHD) have not been sufficiently met everywhere in Finland. We investigated the recorded risk factor rates of ...
  • Metabolic profiling of sourdough fermented wheat and rye bread. 

    Koistinen VM; Mattila O; Katina K; Poutanen K; Aura AM; Hanhineva (Springer Nature, 2018)
    Sourdough fermentation by lactic acid bacteria is commonly used in bread baking, affecting several attributes of the final product. We analyzed whole-grain wheat and rye breads and doughs prepared with baker’s yeast or a ...
  • Nonconvulsive status epilepticus in rats leads to brain pathology 

    Avdic, U; Ahl, M; Chugh, D; Ali, I; Chary, K; Sierra, A; Ekdahl, CT (Wiley, 2018)
    Objective Status epilepticus (SE) is an abnormally prolonged epileptic seizure that if associated with convulsive motor symptoms is potentially life threatening for a patient. However, 20%‐40% of patients with SE lack ...
  • Bayesian aerosol retrieval algorithm for MODIS AOD retrieval over land 

    Lipponen, Antti; Mielonen, Tero; Pitkänen, Mikko R A; Levy, Robert C; Sawyer, Virginia R; Romakkaniemi, Sami; Kolehmainen, Ville; Arola, Antti (Copernicus GmbH, 2018)
    We have developed a Bayesian aerosol retrieval (BAR) algorithm for the retrieval of aerosol optical depth (AOD) over land from the Moderate Resolution Imaging Spectroradiometer (MODIS). In the BAR algorithm, we simultaneously ...
  • Small spatial variability in methane emission measured from a wet patterned boreal bog 

    Korrensalo, Aino; Männistö, Elisa; Alekseychik, Pavel; Mammarella, Ivan; Rinne, Janne; Vesala, Timo; Tuittila, Eeva-Stiina (Copernicus GmbH, 2018)
    We measured methane fluxes of a patterned bog situated in Siikaneva in southern Finland from six different plant community types in three growing seasons (2012–2014) using the static chamber method with chamber exposure ...
  • Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis 

    Cajanus, A; Hall, A; Koikkalainen, J; Solje, E; Tolonen, A; Urhemaa, T; Liu, Y; Haanpää, RM; Hartikainen, P; Helisalmi, S; Korhonen, V; Rueckert, D; Hasselbalch, S; Waldemar, G; Mecocci, P; Vanninen, R; van Gils, M; Soininen, H; Lötjönen, J; Remes, AM (S. Karger AG, 2018)
    Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective ...
  • Crayfish plague in Japan: A real threat to the endemic Cambaroides japonicus 

    Martín-Torrijos, L; Kawai, T; Makkonen, J; Jussila, J; Kokko, H; Diéguez-Uribeondo, J (Public Library of Science (PLoS), 2018)
    Global introductions of aquatic species and their associated pathogens are threatening worldwide biodiversity. The introduction of two North American crayfish species, Procambarus clarkii and Pacifastacus leniusculus, into ...
  • Comparison of metal/polymer back reflectors with half-sphere, blazed, and pyramid gratings for light trapping in III-V solar cells 

    Aho, Timo; Guina, Mircea; Elsehrawy, Farid; Cappelluti, Federica; Raappana, Marianna; Tukiainen, Antti; Alam, A B M Khairul; Vartiainen, Ismo; Kuittinen, Markku; Niemi, Tapio (The Optical SocietyYhdysvallat (USA), 2018)
    We report on the fabrication of diffraction gratings for application as back contact reflectors. The gratings are designed for thin-film solar cells incorporating absorbers with bandgap slightly lower than GaAs, i.e. InAs ...
  • Assessing Biodiversity in Boreal Forests with UAV-Based Photogrammetric Point Clouds and Hyperspectral Imaging 

    Saarinen, Ninni; Vastaranta, Mikko; Nasi, Roope; Rosnell, Tomi; Hakala, Teemu; Honkavaara, Eija; Wulder, Michael A.; Luoma, Ville; Tommaselli, Antonio M. G.; Imai, Nilton N.; Ribeiro, Eduardo A. W.; Guimaraes, Raul B.; Holopainen, Markus; Hyyppa, Juha (MDPI AG, 2018)
    Forests are the most diverse terrestrial ecosystems and their biological diversity includes trees, but also other plants, animals, and micro-organisms. One-third of the forested land is in boreal zone; therefore, changes ...
  • Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE 

    Yadak, Rana; Cabrera-Pérez, Raquel; Torres-Torronteras, Javier; Bugiani, Marianna; Haeck, Joost C; Huston, Marshall W; Bogaerts, Elly; Goffart, Steffi; Jacobs, Edwin H; Stok, Merel; Leonardelli, Lorena; Biasco, Luca; Verdijk, Robert M; Bernsen, Monique R;, Ruijter, George; Martí, Ramon; Wagemaker, Gerard; van Til, Niek P; de Coo, Irenaeus F M (Elsevier BV, 2018)
    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by thymidine phosphorylase (TP) deficiency resulting in systemic accumulation of thymidine (d-Thd) and deoxyuridine ...
  • Sediment diffusion method improves wastewater nitrogen removal in the receiving lake sediments 

    Aalto, SL; Saarenheimo, J; Ropponen, J; Juntunen, J; Rissanen, AJ; Tiirola, M (Elsevier BV, 2018)
    Sediment microbes have a great potential to transform reactive N to harmless N2, thus decreasing wastewater nitrogen load into aquatic ecosystems. Here, we examined if spatial allocation of the wastewater discharge by a ...
  • Career path from a dentist to a leader 

    Tuononen, Tiina A; Suominen, Anna Liisa; Lammintakanen, Johanna (Emerald, 2018)
    Purpose – The purpose of this paper was to study the career paths of leaders with a career background as a dentist from basic degree to chief or executive leadership positions and individual factors that influenced their ...
  • Utilizing multilingual language data in (nearly) real time: the case of the Nordic Tweet Stream 

    Laitinen, Mikko; Lundberg, Jonas; Levin, Magnus; Lakaw, Alexander (Know-Center, 2017)
    This paper presents the Nordic Tweet Stream, a cross-disciplinary digital humanities project that downloads Twitter messages from Denmark, Finland, Iceland, Norway and Sweden. The paper first introduces some of the technical ...
  • Intersectionality at work: The case of Ruth Bates Harris and NASA 

    Ruel, Stefanie; Mills, Albert J; Thomas, Janice L (Ephemera Editorial Collective in association with MayFlyBooks, 2018)
    One challenge we face as diversity and gender scholars is how to apply intersectionality in organizational studies. We present one possible application of intersectionality to demonstrate that it can be put to work beyond ...
  • Fabrication of hybrid optical line generator by direct machining 

    Saastamoinen, Toni; Vayrynen, Juha; Mutanen, Jarkko; Tuovinen, Hemmo; Eronen, Anni; Monkkonen, Kari; Kuittinen, Markku (The Optical Society, 2018)
    In this study, a mold of a line generator consisting of a cylindrical lens array with a triangular diffractive grating was ultra-precision diamond machined with Moore 350FG 5-axis ultra-precision machine. The design and ...
  • Characterisation of Pore Structures of Pharmaceutical Tablets: A Review 

    Markl, D; Strobel, A; Schlossnikl, R; Bøtker, J; Bawuah, P; Ridgway, C; Rantanen, J; Rades, T; Gane, P; Peiponen, KE; Zeitler, JA (Elsevier BVAlankomaat, 2018)
    Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly ...

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