• Evaluating combinations of diagnostic tests to discriminate different dementia types 

  Bruun, Marie; Rhodius-Meester, Hanneke FM; Koikkalainen, Juha; Baroni, Marta; Gjerum, Le; Lemstra, Afina W; Barkhof, Frederik; Remes, Anne M; Urhemaa, Timo; Tolonen, Antti; Rueckert, Daniel; van Gils, Mark; Frederiksen, Kristian S; Waldemar, Gunhild; Scheltens, Philip; Mecocci, Patrizia; Soininen, Hilkka; Lötjönen, Jyrki; Hasselbalch, Steen G; van der Flier, Wiesje M (Elsevier BV, 2018)

  Introduction We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia. Methods In this multicenter study, we included 356 patients ...

• Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations 

  Barrios, C; Zierer, J; Würtz, P; Haller, T; Metspalu, A; Gieger, C; Thorand, B; Meisinger, C; Waldenberger, M; Raitakari, O; Lehtimäki, T; Otero, S; Rodríguez, E; Pedro-Botet, J; Kähönen, M; Ala-Korpela, M; Kastenmüller, G; Spector, TD; Pascual, J; Menni, C (Springer Nature America, Inc, 2018)

  Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent ...

• Mixing state and particle hygroscopicity of organic-dominated aerosols over the Pearl River Delta region in China 

  Hong, Juan; Xu, Hanbing; Tan, Haobo; Yin, Changqing; Hao, Liqing; Li, Fei; Cai, Mingfu; Deng, Xuejiao; Wang, Nan; Su, Hang; Cheng, Yafang; Wang, Lin; Petäjä, Tuukka; Kerminen, Veli-Matti (Copernicus GmbHSaksa, 2018)

  Simultaneous measurements of aerosol hygroscopicity and particle-phase chemical composition were performed at a suburban site over the Pearl River Delta region in the late summer of 2016 using a self-assembled hygroscopic ...

• Intraobserver and interobserver reliability of recategorized Neer classification in differentiating 2-part surgical neck fractures from multi-fragmented proximal humeral fractures in 116 patients 

  Sumrein, BO; Mattila, VM; Lepola, V; Laitinen, MK; Launonen, AP; Paloneva, J; Jonsson, K; Wolf, O; Ström, P; Berg, H; Felländer-Tsai, L; Mechlenburg, I; Døssing, K; Østergaard, H; Rahnel, T; Märtson, A (Elsevier BVYhdysvallat (USA), 2018)

  Background Optimal fracture classification should be simple and reproducible and should guide treatment. For proximal humeral fractures, the Neer classification is commonly used. However, intraobserver and interobserver ...

• Surface energy exchange in pristine and managed boreal peatlands 

  Alekseychik, P; Mammarella, I; Lindroth, A; Lohila, A; Aurela, M; Laurila, T; Kasurinen, V; Lund, M; Rinne, J; Nilsson, M B; Peichl, M; Minkkinen, K; Shurpali, N J; Tuittila, E -S; Martikainen, P J; Tuovinen, J -P; Vesala, T (2018)

  Surface–atmosphere energy exchange is strongly ecosystem-specific. At the same time, as the energy balance constitutes responses of an ecosystem to environmental stressors including precipitation, humidity and solar ...

• Scanning of skin gloss by a diffractive optical element-based handheld glossmeter 

  Asamoah, Benjamin; Peiponen, Kai-Erik (Springer Nature America, IncJapani, 2018)

  Skin specular gloss (referred to as “gloss’’) determination is important in dermatology and cosmetic industry as it gives an indication of the skin health and beauty. Its accurate determination is, therefore, necessary. ...

• Systemic Estrogen Use and Discontinuation After Alzheimer's Disease Diagnosis in Finland 2005-2012: A Nationwide Exposure-Matched Cohort Study 

  Tolppanen, AM; Tiihonen, M; Taipale, H; Koponen, M; Tanskanen, A; Lavikainen, P; Tiihonen, J; Hartikainen, S (Springer Nature America, IncSveitsi, 2018)

  Background It is unknown whether cognitive status or diagnosed cognitive decline affects estrogen use. Objectives We assessed how common systemic estrogen use was among community-dwellers with Alzheimer’s disease (AD) ...

• Consent recommendations for research and international data sharing involving persons with dementia 

  Thorogood, A; Mäki-Petäjä-Leinonen, A; Brodaty, H; Dalpé, G; Gastmans, C; Gauthier, S; Gove, D; Harding, R; Knoppers, BM; Rossor, M; Bobrow, M (Elsevier BV, 2018)

  Consent is generally required for research and sharing rich individual-level data but presents additional ethical and legal challenges where participants have diminished decision-making capacity. We formed a multi-disciplinary ...

• Research challenges for cultural ecosystem services and public health in (peri-)urban environments 

  Chen, X; de Vries, S; Assmuth, T; Dick, J; Hermans, T; Hertel, O; Jensen, A; Jones, L; Kabisch, S; Lanki, T; Lehmann, I; Maskell, L; Norton, L; Reis, S (Elsevier BVAlankomaat, 2018)

  Urbanization is a global trend, and consequently the quality of urban environments is increasingly important for human health and wellbeing. Urban life-style is typically associated with low physical activity and sometimes ...

• Size matters more than shape: Ingestion of primary and secondary microplastics by small predators 

  Lehtiniemi, Maiju; Hartikainen, Samuel; Näkki, Pinja; Engström-Öst, Jonna; Koistinen, Arto; Setälä, Outi (Elsevier BV, 2018)

  Experimental studies have shown how microplastics are taken up by various aquatic organisms. Most of these studies have been carried out with small (<100 μm) symmetrically shaped primary microplastics (beads) which are not ...

• Stable carbon isotopic composition of peat columns, subsoil and vegetation on natural and forestry-drained boreal peatlands 

  Nykänen, Hannu; Mpamah, Promise A; Rissanen, Antti J (Sveitsi, 2018)

  We studied natural and forestry-drained peatlands to examine the effect of over 34 years lowered water table on the δ13C values of vegetation, bulk peat and subsoil. In the seven studied sites, δ13C in the basal peat layer ...

• Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics 

  Kaczor Agnieszka A; Silva Andrea G; Loza Maria I; Kolb Peter; Castro Marián; Poso Antti (Wiley-Blackwell, 2016)

  Structure‐based virtual screening using a D2 receptor homology model was performed to identify dopamine D2 receptor ligands as potential antipsychotics. From screening a library of 6.5 million compounds, 21 were selected ...

• Antiepileptic Drug Use and the Risk of Stroke Among Community-Dwelling People With Alzheimer Disease: A Matched Cohort Study 

  Sarycheva, Tatyana; Lavikainen, Piia; Taipale, Heidi; Tiihonen, Jari; Tanskanen; Antti; Hartikainen, Sirpa; Tolppanen, Anna-Maija (Ovid Technologies (Wolters Kluwer Health), 2018)

  Background People with Alzheimer disease (AD) are more predisposed to seizures than older people in general, and use of antiepileptic drugs (AEDs) is more frequent. AED use has been linked to a higher risk of vascular ...

• Detection of Hyperexcitability by fMRI After Experimental Traumatic Brain Injury 

  Huttunen, JK; Airaksinen, AM; Barba, C; Colicchio, G; Niskanen, JP; Shatillo, A; Sierra Lopez, A; Ndode-Ekane, XE; Pitkanen, A; Gröhn, O (Mary Ann Liebert Inc, 2018)

  Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. Given that increased neuronal activity in the brain triggers a blood oxygenation level–dependent (BOLD) response ...

• Emerging Roles of Non-Coding RNA Transcription 

  Kaikkonen, Minna U; Adelman, Karen (Elsevier BV, 2018)

  Metazoan genomes are broadly transcribed by RNA polymerase II (RNAPII), but surprisingly few of these RNAs encode proteins. Accordingly, there is great interest in understanding the origins and potential roles of the vast ...

• Eco-immunology in the cold: the role of immunity in shaping the overwintering survival of ectotherms 

  Ferguson, Laura V; Kortet, Raine; Sinclair, Brent J (The Company of Biologists, 2018)

  The effect of temperature on physiology mediates many of the challenges that ectotherms face under climate change. Ectotherm immunity is thermally sensitive and, as such, environmental change is likely to have complex ...

• Sosioekonomisesti heikommassa asemassa olevien kiinnostus ja mahdollisuudet digitaalisten terveyspalveluiden käyttöön 

  Tilles-Tirkkonen, Tanja; Lappi, Jenni; Karhunen, Leila; Harjumaa, Marja; Absetz, Pilvikki; Pihlajamäki, Jussi (Suomi, 2018)

• Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients 

  Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M (Springer Nature America, Inc, 2018)

  Idiopathic normal pressure hydrocephalus (iNPH) is a neuropathology with unknown cause characterised by gait impairment, cognitive decline and ventriculomegaly. These patients often present comorbidity with Alzheimer’s ...

• A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants 

  Jääskeläinen, T; Kärkkäinen, O; Jokkala, J; Litonius, K; Heinonen, S; Auriola, S; Lehtonen, M; Hanhineva, K; Laivuori, H; FINNPEC (Springer Nature America, Inc, 2018)

  Preeclampsia (PE) is a complex pregnancy disorder. It is not extensively known how the metabolic alterations of PE women contribute to the metabolism of newborn. We applied liquid chromatography-mass spectrometry (LC-MS) ...

• Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype 

  Liukkonen, J; Gürsoy, UK; Könönen, E; Gürsoy, M; Metso, J; Salminen, A; Kopra, E; Jauhiainen, M; Mäntylä, P Buhlin K, Paju S, Sorsa T, Nieminen MS, Lokki ML, Sinisalo J, Pussinen PJ (SAGE Publications, 2018)

  Genetic factors play a role in periodontitis. Here we examined whether the risk haplotype of MHC class III region BAT1-NFKBIL1-LTA and lymphotoxin-α polymorphisms associate with salivary biomarkers of periodontal disease. ...

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