Browsing by Subject "Genome-wide association studies"

Now showing items 1-6 of 6

    • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass 

      Zillikens M Carola; Demissie Serkalem; Hsu Yi-Hsiang; Yerges-Armstrong Laura M; Chou Wen-Chi; Stolk Lisette; Livshits Gregory; Broer Linda; Johnson Toby; Koller Daniel L; Kutalik Zoltán; Luan Jian'an; Malkin Ida; Ried Janina S; Smith Albert V; Thorleifsson Gudmar; Vandenput Liesbeth; Zhao Jing Hua; Zhang Weihua; Aghdassi Ali et al. (incl. Cederberg Henna) (Springer Nature, 2017)
      Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and ...
      info:eu-repo/semantics/article

    • No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes 

      Eynon N; Filipenko ML; Garton FC; Generozov EV; Govorun VM; Houweling PJ; Kawahara T; Kostryukova ES; Kulemin NA; Larin AK; Maciejewska-Karlowska A et al. (incl. Rauramaa R) (Public Library of Science (PLoS), 2016)
      There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world ...
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    • Novel genetic loci associated with hippocampal volume 

      Hibar DP; Adams HH; Jahanshad N; Chauhan G; Stein JL; Hofer E; Renteria ME; Bis JC; Arias-Vasquez A; Ikram MK; Desrivières S; Vernooij MW; Abramovic L; Alhusaini S; Amin N; Andersson M; Arfanakis K; Aribisala BS; Armstrong NJ; Athanasiu L et al. (Springer Nature, 2017)
      The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several ...
      info:eu-repo/semantics/article

    • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape 

      Ried JS; Jeff M J; Chu AY; Bragg-Gresham JL; van Dongen J; Huffman JE; Ahluwalia TS; Cadby G; Eklund N; Eriksson J; Esko T; Feitosa MF; Goel A; Gorski M; Hayward C; Heard-Costa NL; Jackson AU; Jokinen E; Kanoni S; Kristiansson K et al (Springer Nature, 2016)
      Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...
      info:eu-repo/semantics/article

    • Sequence data and association statistics from 12,940 type 2 diabetes cases and controls 

      Jason F; Fuchsberger C; Mahajan A; Teslovich TM; Agarwala V; Gaulton KJ; Caulkins L; Koesterer R; Ma C; Moutsianas L; McCarthy DJ; Rivas MA; Perry JRB; Sim X; Blackwell TW; Robertson NR; Rayner NW; Kuusisto J; Kuulasmaa T et al (Springer Nature, 2017)
      To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 ...
      info:eu-repo/semantics/article

    • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek; Esko, Tõnu; Fall, Tove; Yaluri, Alena (Public Library of Science (PLoS), 2015)
      Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and ...
      info:eu-repo/semantics/article