Browsing Terveystieteiden tiedekunta by Subject "anticancer compounds"

Now showing items 1-1 of 1

    • HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents 

      Waitman, Karoline B.; de Almeida, Larissa C.; Primi, Marina C.; Carlos, Jorge A.E.G.; Ruiz, Claudia; Kronenberger, Thales; Laufer, Stefan; Goettert, Marcia Ines; Poso, Antti; Vassiliades, Sandra V.; de Souza, Vinícius A.M.; Toledo, Mônica F.Z. J.; Hassimotto, Neuza M.A.; Cameron, Michael D.; Bannister, Thomas D.; Costa-Lotufo, Letícia V.; Machado-Neto, João A.; Tavares, Maurício T.; Parise-Filho, Roberto (Elsevier B.V., 2024)
      A series of hybrid inhibitors, combining pharmacophores of known kinase inhibitors bearing anilino-purines (ruxolitinib, ibrutinib) and benzohydroxamate HDAC inhibitors (nexturastat A), were generated in the present study. ...