Now showing items 1-20 of 1358

    • AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study 

      Kärkkäinen, Olli; Kupila, Jukka; Häkkinen, Merja; Laukkanen, Virpi; Tupala, Erkki; Kautiainen, Hannu; Tiihonen, Jari; Storvik, Markus (Elsevier BV, 2013)
      Dysfunction of the brain glutamate system has been associated with alcoholism. Ionotropic glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) play an important role in both neurotransmission ...

    • Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics 

      Kärkkäinen, Olli K; Lehtonen, Marko; Laukkanen, Virpi; Tupala, Erkki; Hyytiä, Petri; Kautiainen, Hannu; Tiihonen, Jari; Callaway, JC; Storvik, Markus (Elsevier BV, 2013)
      Accumulating evidence continues to link certain aspects of the endogenous cannabinoid (EC) system with alcohol dependence, negative-reinforcement learning, and the modulation of stress responses. Specific alterations in ...

    • Lower [3H]Citalopram Binding in Brain Areas Related to Social Cognition in Alcoholics 

      Kärkkäinen, Olli; Laukkanen, Virpi; Haukijärvi, Tuija; Kautiainen, Hannu; Tiihonen, Jari; Storvik, Markus (Elsevier BV, 2014)
      In the present study, putative alterations in the serotonin transporter density were evaluated in anterior and posterior insula, posterior cingulate cortex, dorsolateral and dorsomedial prefrontal cortex, hippocampus, ...

    • Validation of protein carbonyl measurement: A multi-centre 

      Augustyniak, Edyta; Adam, Aisha; Wojdyla, Katarzyna; Rogowska-Wrzesinska, Adelina; Willetts, Rachel; Korkmaz, Ayhan; Atalay, Mustafa; Weber, Daniela; Grune, Tilman; Borsa, Claudia; Gradinaru, Daniela; Chand Bollineni, Ravi; Fedorova, Maria; Griffiths, Helen R. (Elsevier BV, 2014)
      Protein carbonyls are widely analysed as a measure of protein oxidation. Several different methods exist for their determination. A previous study had described orders of magnitude variance that existed when protein carbonyls ...

    • SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin 

      Toropainen, Sari; Malinen, Marjo; Kaikkonen, Sanna; Jääskeläinen, Tiina; Sahu, Biswajyoti; Jänne, Olli A.; Palvimo, Jorma J. (Oxford University Press on behalf of Nucleic Acids Research., 2014)
      Androgen receptor (AR) is a ligand-activated transcription factor that plays a central role in the development and growth of prostate carcinoma. PIAS1 is an AR- and SUMO-interacting protein and a putative transcriptional ...

    • Opinions on conscientious objection to induced abortion among Finnish medical and nursing students and professionals 

      Nieminen, Petteri; Lappalainen, Saara; Ristimäki, Pauliina; Myllykangas, Markku; Mustonen, Anne-Mari (BioMed Central, 2015)
      Background: Conscientious objection (CO) to participating in induced abortion is not present in the Finnish health care system or legislation unlike in many other European countries. Methods: We conducted a questionnaire ...

    • IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification 

      Rytkönen-Nissinen, Marja; Saarelainen, Soili; Randell, Jukka; Häyrinen, Jukka; Kalkkinen, Nisse; Virtanen, Tuomas (The Korean Academy of Asthma, Allergy and Clinical Immunology and The Korean Academy of Pediatric Al, 2015)
      Purpose Divergent results on the IgE reactivity of dog-allergic subjects to Can f 4 have been reported. The aim of this study was to evaluate the significance of Can f 4 in dog allergy and to develop an immunochemical ...

    • Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles 

      Rilla, Kirsi; Koistinen, Arto; Koistinen, Ville; Arjonen, Antti; Kärnä, Riikka; Tammi, Markku (Hindawi Publishing Corporation, 2015)
      Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. The ...

    • Biological interpretation of genome-wide association studies using predicted gene functions 

      Pers, Tune H.; Karjalainen, Juha M.; Chan, Yingleong; Westra, Harm-Jan; Wood, Andrew R.; Yang, Jian; Lui, Julian C.; Vedantam, Sailaja; Gustafsson, Stefan; Esko, Tonu; Frayling, Tim; Speliotes, Elizabeth K.; Boehnke, Michael; Raychaudhuri, Soumya; Fehrmann, Rudolf S. N.; Hirschhorn, Joel N.; Franke, Lude; Kuusisto, Johanna (Nature Publishing Group, 2015)
      The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions ...

    • Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view 1 

      Carlberg, Carsten; Molnár, Ferdinand (Canadian Science Publishing, 2015)
      Vitamin D3 is one of the few natural compounds that has, via its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation. For efficiently ...

    • Hyaluronan synthase 1 : a mysterious enzyme with unexpected functions 

      Siiskonen, Hanna; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi (Frontiers Media SA, 2015)
      Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the ...

    • Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation 

      Ziyatdinova, Sofya; Viswanathan, Jayashree; Hiltunen, Mikko; Tanila, Heikki; Pitkänen, Asla (Elsevier BV, 2015)
      Patients with Alzheimer´s disease are at increased risk for unprovoked seizures and epilepsy compared with age-matched controls. Experimental evidence suggests that neuronal hyperexcitability and epilepsy can be triggered ...

    • Experiential Thinking in Creationism - A Textual Analysis 

      Nieminen, Petteri; Ryökäs, Esko; Mustonen, Anne-Mari (PLOS, 2015)
      Creationism is a religiously motivated worldview in denial of biological evolution that has been very resistant to change. We performed a textual analysis by examining creationist and pro-evolutionary texts for aspects of ...

    • Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas subtitle: 

      Dali-Youcef, Nassim; Froelich, Sébastien; Moussallieh, François-Marie; Chibbaro, Salvatore; Noël, Georges; Namer, Izzie J.; Heikkinen, Sami; Auwerx, Johan (Nature Publishing Group, 2015)
      Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone ...

    • Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene 

      Knowles, Joshua W.; Xie, Weijia; Zhang, Zhongyang; Chennemsetty, Indumathi; Assimes, Themistocles L.; Paananen, Jussi; Hansson, Ola; Pankow, James; Goodarzi, Mark O.; Carcamo-Orive, Ivan; Morris, Andrew P.; Chen, Yii-Der I.; Mäkinen, Ville-Petteri; Ganna, Andrea; Mahajan, Anubha; Guo, Xiuqing; Abbasi, Fahim; Greenawalt, Danielle M.; Lum, Pek; Molony, Cliona; Lind, Lars; Lindgren, Cecilia; Raffel, Leslie J.; Tsao, Philip S.; Schadt, Eric E.; Rotter, Jerome I.; Sinaiko, Alan; Reaven, Gerald; Yang, Xia; Hsiung, Chao A.; Groop, Leif; Cordell, Heather J.; Laakso, Markku; Hao, Ke; Ingelsson, Erik; Frayling, Timothy M.; Weedon, Michael N.; Walker, Mark; Quertermous, Thomas (American Society for Clinical Investigation, 2015)
      Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, ...

    • Relevance of Vitamin D Receptor Target Genes for Monitoring the Vitamin D Responsiveness of Primary Human Cells 

      Vukić, Maja; Neme, Antonio; Seuter, Sabine; Saksa, Noora; de Mello, Vanessa D. F.; Nurmi, Tarja; Uusitupa, Matti; Tuomainen, Tomi-Pekka (Public Library of Science (PLoS), 2015)
      Vitamin D3 has transcriptome- and genome-wide effects and activates, via the binding of its metabolite 1α,25-dihydroxyvitamin D3 to the transcription factor vitamin D receptor (VDR), several hundred target genes. Using ...

    • Multiplex eukaryotic transcription (in)activation : timing, bursting and cycling of a ratchet clock mechanism 

      Rybakova, Katja N.; Bruggeman, Frank J.; Tomaszewska, Aleksandra; Moné, Martijn J.; Carlberg, Carsten; Westerhoff, Hans V. (Public Library of Science (PLoS), 2015)
      Activation of eukaryotic transcription is an intricate process that relies on a multitude of regulatory proteins forming complexes on chromatin. Chromatin modifications appear to play a guiding role in protein-complex ...

    • Secular trends affect timing of emergence of permanent teeth 

      Eskeli, Ritva; Lösönen, Matias; Ikävalko, Tiina; Myllykangas, Riitta; Lakka, Timo; Laine-Alava, Maija T (The Angle Orthodontist (EH Angle Education & Research Foundation), 2015)
      Objective:  To examine the expression of possible secular trend in timing of the emergence of permanent teeth in Finnish children over the past few decades, considering the differences between genders. Materials and ...

    • High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation 

      Sokka, Miiko; Rilla, Kirsi; Miinalainen, Ilkka; Pospiech, Helmut; Syväoja, Juhani E. (Oxford University Press (OUP), 2015)
      Nucleoli are not only organelles that produce ribosomal subunits. They are also overarching sensors of different stress conditions and they control specific nucleolar stress pathways leading to stabilization of p53. During ...

    • Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells 

      Lindqvist, Julia; Imanishi, Susumu Y.; Torvaldson, Elin; Malinen, Marjo; Remes, Mika; Örn, Fanny; Palvimo, Jorma J.; Eriksson, John E. (American Society for Cell Biology (ASCB), 2015)
      Contrary to cell cycle–associated cyclin-dependent kinases, CDK5 is best known for its regulation of signaling processes in differentiated cells and its destructive activation in Alzheimer's disease. Recently, CDK5 has ...