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Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level
(Public Library of Science (PLoS), 2017)
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Objective
The potential of high-density lipoproteins (HDL) to facilitate cholesterol removal from arterial foam cells is a key function of HDL. We studied whether cholesterol efflux to serum and HDL subfractions is impaired ...
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
(Springer Nature, 2017)
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Background
Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic ...
Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism - The Young Finns Study
(Springer Nature, 2016)
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MicroRNAs are involved in disease development and may be utilized as biomarkers. We investigated the association of blood miRNA levels and a) fatty liver (FL), b) lipoprotein and lipid pathways involved in liver lipid ...
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids
(BioMed Central Ltd., 2016)
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Aims
An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship ...
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis
(Oxford University Press (OUP), 2016)
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Motivation
A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex ...
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology : a Primer on -Omic Technologies
(Oxford University Press (OUP), 2017)
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Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel biomarkers for cardiometabolic diseases and clarified the molecular associations of established risk factors. A quantitative metabolomics ...