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dc.contributor.authorJarvis D
dc.contributor.authorMitchell JS
dc.contributor.authorLaw PJ
dc.contributor.authorPalin K
dc.contributor.authorTuupanen S
dc.contributor.authorGylfe A
dc.contributor.authorHänninen UA
dc.contributor.authorCajuso T
dc.contributor.authorTanskanen T
dc.contributor.authorKondelin J
dc.contributor.authorKaasinen E
dc.contributor.authorSarin A-P
dc.contributor.authorKaprio J
dc.contributor.authorEriksson JG
dc.contributor.authorRissanen H
dc.contributor.authorKnekt P
dc.contributor.authorPukkala E
dc.contributor.authorJousilahti P
dc.contributor.authorSalomaa V
dc.contributor.authorRipatti S
dc.contributor.authorPalotie A
dc.contributor.authorJärvinen H
dc.contributor.authorRenkonen-Sinisalo L
dc.contributor.authorLepistö A
dc.contributor.authorBöhm J
dc.contributor.authorMeklin J-P
dc.contributor.authorAl-Tassan NA
dc.contributor.authorPalles C
dc.contributor.authorMartin L
dc.contributor.authorBarclay E
dc.contributor.authorFarrington SM
dc.contributor.authorTimofeeva MN
dc.contributor.authorMeyer BF
dc.contributor.authorWakil SM
dc.contributor.authorCampbell H
dc.contributor.authorSmith C.G
dc.contributor.authorIdziaszczyk S
dc.contributor.authorMaughan TS
dc.contributor.authorKaplan R
dc.contributor.authorKerr R
dc.contributor.authorKerr D
dc.contributor.authorBuchanan DD
dc.contributor.authorWin AK
dc.contributor.authorHopper JL
dc.contributor.authorJenkins MA
dc.contributor.authorLindor NM
dc.contributor.authorNewcomb PA
dc.date.accessioned2017-01-19T19:20:52Z
dc.date.available2017-01-19T19:20:52Z
dc.date.issued2016-06-23
dc.identifier10.1038/bjc.2016.188fi_FI
dc.identifier.issn0007-0920
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/231
dc.descriptionArticle
dc.description.abstractBackground: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. Methods: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls. Results: In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02–1.49, P=0.033), 1.59 (95% CI: 1.08–2.34, P=0.019) and 1.07 (95% CI: 1.03–1.13, P=0.018), respectively. There was no evidence for association between birth weight and CRC (OR=1.22, 95% CI: 0.89–1.67, P=0.22). Combining these data with a concurrent MR-based analysis for BMI and WHR with CRC risk (totalling to 18 190 cases, 27 617 controls) provided increased support, ORs for BMI and WHR were 1.26 (95% CI: 1.10–1.44, P=7.7 × 10−4) and 1.40 (95% CI: 1.14–1.72, P=1.2 × 10−3), respectively. Conclusions: These data provide further evidence for a strong causal relationship between adiposity and the risk of developing CRC highlighting the urgent need for prevention and treatment of adiposity.fi_FI
dc.language.isoENfi_FI
dc.publisherCancer Research UKfi_FI
dc.relation.ispartofseriesBRITISH JOURNAL OF CANCER
dc.relation.urihttp://doi.org/10.1038/bjc.2016.188fi_FI
dc.rightsCC BY-NC-SA https://creativecommons.org/licenses/by-nc-sa/4.0/fi_FI
dc.subjectMendelian randomisationfi_FI
dc.subjectadiposityfi_FI
dc.subjectcolorectal cancerfi_FI
dc.titleMendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancerfi_FI
dc.typehttp://purl.org/eprint/type/JournalArticle
dc.description.versionpublisher's pdffi_FI
dc.contributor.departmentSchool of Medicine / Clinical Medicine
uef.solecris.id42543083
eprint.statushttp://purl.org/eprint/status/PeerReviewedfi_FI
dc.type.publicationinfo:eu-repo/semantics/article
dc.rights.accessrights© Nature Publishing Groupfi_FI
uef.citationinfo.issue2
uef.citationinfo.pages266-272
dc.relation.doi10.1038/bjc.2016.188
dc.description.reviewstatushttp://purl.org/eprint/status/PeerReviewed
dc.format.pagerange266-272
dc.relation.issn0007-0920
dc.relation.issue2


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