Data from: Assessment of dysmyelination with RAFFn MRI: application to murine MPS I

Satzer, David (University of Minnesota); DiBartolomeo, Christina (University of Minnesota); Ritchie, Michael M. (University of Minnesota); Storino, Christine (University of Minnesota); Liimatainen, Timo (University of Eastern Finland); Hakkarainen, Hanne (University of Eastern Finland); Idiyatullin, Djaudat (University of Minnesota); Mangia, Silvia (University of Minnesota); Michaeli, Shalom (University of Minnesota); Parr, Ann M. (University of Minnesota); Low, Walter C. (University of Minnesota)

Date

2015-12-12

Author(s)

Satzer, David (University of Minnesota)

DiBartolomeo, Christina (University of Minnesota)

Ritchie, Michael M. (University of Minnesota)

Storino, Christine (University of Minnesota)

Liimatainen, Timo (University of Eastern Finland)

Hakkarainen, Hanne (University of Eastern Finland)

Idiyatullin, Djaudat (University of Minnesota)

Mangia, Silvia (University of Minnesota)

Michaeli, Shalom (University of Minnesota)

Parr, Ann M. (University of Minnesota)

Low, Walter C. (University of Minnesota)

Unique identifier

doi:10.5061/dryad.ng64q

Metadata

Show full item record

Research data

Citation

Satzer, David (University of Minnesota). DiBartolomeo, Christina (University of Minnesota). Ritchie, Michael M. (University of Minnesota). Storino, Christine (University of Minnesota). Liimatainen, Timo (University of Eastern Finland). Hakkarainen, Hanne (University of Eastern Finland). Idiyatullin, Djaudat (University of Minnesota). Mangia, Silvia (University of Minnesota). Michaeli, Shalom (University of Minnesota). Parr, Ann M. (University of Minnesota). Low, Walter C. (University of Minnesota). , Data from: Assessment of dysmyelination with RAFFn MRI: application to murine MPS I, 2015, doi:10.5061/dryad.ng64q.

Licensed under

https://creativecommons.org/publicdomain/zero/1.0/

Abstract

Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P