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dc.contributor.authorKunutsor SK
dc.contributor.authorLaukkanen JA
dc.contributor.authorWhitehouse MR
dc.contributor.authorBlom AW
dc.date.accessioned2017-09-22T10:47:41Z
dc.date.available2017-09-22T10:47:41Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4332
dc.description.abstractPurpose The Mediterranean diet is associated with decreased morbidity and mortality from various chronic diseases. Adherence to a Mediterranean-style diet has been suggested to have protective effects on bone health and decreases the incidence of bone fractures, but the evidence is not clear. We conducted a systematic review and meta-analysis of available observational studies to quantify the association between adherence to a Mediterranean-style diet, as assessed by the Mediterranean Diet Score (MDS), and the risk of fractures in the general population. Methods Relevant studies were identified in a literature search of MEDLINE, EMBASE, Web of Science, and reference lists of relevant studies to October 2016. Relative risks (RRS) with 95% confidence intervals (CIs) were aggregated using random-effects models. Results Five observational studies with data on 353,076 non-overlapping participants and 33,576 total fractures (including 6,881 hip fractures) were included. The pooled fully adjusted RR (95% CI) for hip fractures per 2-point increment in adherence to the MDS was 0.82 (0.71–0.96). Adherence to the MDS was not associated with the risk of any or total fractures based on pooled analysis of only two studies. Conclusion Limited observational evidence supports a beneficial effect of adherence to a Mediterranean-style diet on the incidence of hip fractures. Well-designed intervention studies are needed to elucidate the relationship between adherence to a Mediterranean-style diet and the risk of adverse bone health outcomes such as fractures.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesEUROPEAN JOURNAL OF NUTRITIONen
dc.relation.urihttp://dx.doi.org/10.1007/s00394-017-1432-0en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectMediterranean dieten
dc.subjectBoneen
dc.subjectFracturesen
dc.subjectNutritionen
dc.titleAdherence to a Mediterranean-style diet and incident fractures: pooled analysis of observational evidenceen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
uef.solecris.id46656264en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1007/s00394-017-1432-0en
dc.description.reviewstatuspeerRevieweden
dc.relation.issn1436-6207en
dc.relation.volume[Epub ahead of print 22 March 2017]en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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