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dc.contributor.authorBartuzi D
dc.contributor.authorKaczor AA
dc.contributor.authorMatosiuk D
dc.date.accessioned2017-11-09T11:15:15Z
dc.date.available2017-11-09T11:15:15Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4490
dc.description.abstractIn recent years, our understanding of function of G protein-coupled receptors (GPCRs) has changed from a picture of simple signal relays, transmitting only a particular signal to a particular G protein heterotrimer, to versatile machines, capable of various responses to different stimuli and being modulated by various factors. Some recent reports provide not only the data on ligands/modulators and resultant signals induced by them, but also deeper insights into exact pathways of signal migration and mechanisms of signal transmission through receptor structure. Combination of these computational and experimental data sheds more light on underlying mechanisms of signal transmission and signaling bias in GPCRs. In this review we focus on available clues on allosteric pathways responsible for complex signal processing within GPCRs structures, with particular emphasis on linking compatible in silico- and in vitro-derived data on the most probable allosteric connections.en
dc.language.isoENen
dc.publisherMDPI AGen
dc.relation.ispartofseriesMOLECULESen
dc.relation.urihttp://dx.doi.org/10.3390/molecules22071188en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectGPCRsen
dc.subjectsignalingen
dc.subjectallosteryen
dc.subjectprotein dynamicsen
dc.titleSignaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptorsen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Pharmacy, Activitiesen
uef.solecris.id49586514en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.3390/molecules22071188en
dc.description.reviewstatuspeerRevieweden
dc.format.pagerange1-24en
dc.relation.articlenumber1188en
dc.relation.issn1420-3049en
dc.relation.issue7en
dc.relation.volume22en
dc.rights.accesslevelopenAccessen
dc.type.okmA2en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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