Show simple item record

dc.contributor.authorLottonen-Raikaslehto L
dc.contributor.authorRissanen R
dc.contributor.authorGurzeler E
dc.contributor.authorMerentie M
dc.contributor.authorHuusko J
dc.contributor.authorSchneider JE
dc.contributor.authorLiimatainen T
dc.contributor.authorYlä-Herttuala S
dc.date.accessioned2017-11-13T11:01:48Z
dc.date.available2017-11-13T11:01:48Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/4501
dc.description.abstractCardiac‐specific overexpression of vascular endothelial growth factor (VEGF)‐B167 is known to induce left ventricular hypertrophy due to altered lipid metabolism, in which ceramides accumulate to the heart and cause mitochondrial damage. The aim of this study was to evaluate and compare different imaging methods to find the most sensitive way to diagnose at early stage the progressive left ventricular remodeling leading to heart failure. Echocardiography and cardiovascular magnetic resonance imaging were compared for imaging the hearts of transgenic mice with cardiac‐specific overexpression of VEGF‐B167 and wild‐type mice from 5 to 14 months of age at several time points. Disease progression was verified by molecular biology methods and histology. We showed that left ventricular remodeling is already ongoing at the age of 5 months in transgenic mice leading to heart failure by the age of 14 months. Measurements from echocardiography and cardiovascular magnetic resonance imaging revealed similar changes in cardiac structure and function in the transgenic mice. Changes in histology, gene expressions, and electrocardiography supported the progression of left ventricular hypertrophy. Longitudinal relaxation time in rotating frame (T1ρ) in cardiovascular magnetic resonance imaging could be suitable for detecting severe fibrosis in the heart. We conclude that cardiac‐specific overexpression of VEGF‐B167 leads to left ventricular remodeling at early age and is a suitable model to study heart failure development with different imaging methods.en
dc.language.isoENen
dc.publisherWiley-Blackwellen
dc.relation.ispartofseriesPhysiological Reportsen
dc.relation.urihttp://dx.doi.org/10.14814/phy2.13096en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectcardiovascular imagingen
dc.subjectheart failureen
dc.subjectleft ventricular hypertrophyen
dc.subjectmouse ECGen
dc.subjectvascular endothelial growth factor -Ben
dc.titleLeft ventricular remodeling leads to heart failure in mice with cardiac-specific overexpression of VEGF-B167: echocardiography and magnetic resonance imaging studyen
dc.description.versionpublished versionen
dc.contributor.departmentA.I. Virtanen -instituuttien
uef.solecris.id47866534en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.14814/phy2.13096en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumbere13096
dc.relation.issn2051-817Xen
dc.relation.issue6en
dc.relation.volume5en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record