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dc.contributor.authorMäntyselkä A
dc.contributor.authorJääskeläinen J
dc.contributor.authorEloranta AM
dc.contributor.authorVäistö J
dc.contributor.authorVoutilainen R
dc.contributor.authorOng K
dc.contributor.authorBrage S
dc.contributor.authorLakka TA
dc.contributor.authorLindi V
dc.date.accessioned2017-12-18T07:58:24Z
dc.date.available2017-12-18T07:58:24Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5082
dc.description.abstractObjective Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children. Design and subjects Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years. Measurements Assessment of dietary factors by food records and physical activity and sedentary behaviour by a combined heart rate and movement monitor and a questionnaire. Measurement of serum DHEAS and IGF-1. Results Consumption of low-fibre grain products (standardized regression coefficient β = .118, P = .017) and intake of vegetable protein (β = .100, P = .045) was positively and consumption of sugar-sweetened beverages (β = −.117, P = .018) was inversely associated with DHEAS after adjustment for sex, age and body fat percentage. Energy intake (β = .160, P = .001) was positively associated with IGF-1 adjusting for sex, age and body fat percentage. Vigorous physical activity was inversely associated with DHEAS after adjustment for sex and age (β = −.120, P = .027), and total (β = −.137, P = .007), moderate (β = −.130, P = .012), vigorous (β = −.136, P = .011) and moderate to vigorous physical activity (β = −.160, P = .003) were inversely and total sedentary behaviour (β = .151, P = .003) was positively associated with IGF-1 adjusting for sex and age. None of physical activity measures was associated with DHEAS or IGF-1 after additional adjustment for body fat percentage. Conclusions Lifestyle factors have weak and moderate associations with biochemical markers of adrenarche in prepubertal children. These associations indicate body fat independent and dependent influences of diet and physical activity, respectively.en
dc.language.isoENen
dc.publisherWiley-Blackwellen
dc.relation.ispartofseriesCLINICAL ENDOCRINOLOGYen
dc.relation.urihttp://dx.doi.org/10.1111/cen.13511en
dc.rightsAll rights reserveden
dc.subjectbody fat percentageen
dc.subjectdehydroepiandrosterone sulphateen
dc.subjectinsulin-like growth factor-1en
dc.subjectlean body massen
dc.subjectlifestyle factorsen
dc.titleAssociations of lifestyle factors with serum dehydroepiandrosterone sulfate and insulin-like growth factor-1 concentration in prepubertal childrenen
dc.description.versionfinal draften
dc.contributor.departmentSchool of Medicine / Clinical Medicineen
dc.contributor.departmentSchool of Medicine / Biomedicineen
uef.solecris.id50599036en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© John Wiley & Sons Ltden
dc.relation.doi10.1111/cen.13511en
dc.description.reviewstatuspeerRevieweden
dc.relation.issn0300-0664en
dc.relation.volume[Epub ahead of print 29 Nov 2017]en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
uef.solecris.openaccessEi


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