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dc.contributor.authorWalle P
dc.contributor.authorTakkunen M
dc.contributor.authorMännistö V
dc.contributor.authorVaittinen M
dc.contributor.authorKäkelä P
dc.contributor.authorÅgren J
dc.contributor.authorSchwab U
dc.contributor.authorLindström J
dc.contributor.authorTuomilehto J
dc.contributor.authorUusitupa M
dc.contributor.authorPihlajamäki J.
dc.date.accessioned2018-01-09T13:24:23Z
dc.date.available2018-01-09T13:24:23Z
dc.date.issued2017
dc.identifier.urihttps://erepo.uef.fi/handle/123456789/5142
dc.description.abstractBackground: The effects of obesity surgery on serum and adipose tissue fatty acid (FA) profile and FA metabolism may modify the risk of obesity-related diseases. Methods: We measured serum (n=122) and adipose tissue (n=24) FA composition and adipose tissue mRNA expression of genes regulating FA metabolism (n=100) in participants of the Kuopio Obesity Surgery Study (KOBS, age 47.2±8.7 years, BMI 44.6±6.0, 40 men, 82 women) before and one year after obesity surgery. As part of the surgery protocol, all the subjects were instructed to add sources of unsaturated fatty acids, such as rapeseed oil and fatty fish, into their diet. The results were compared with changes in serum FA composition in 122 subjects from the Finnish Diabetes Prevention study (DPS) (age 54.3±7.1 years, BMI 32.2±4.6, 28 men, 94 women). Results: The proportion of saturated FAs decreased and the proportion of n-3 and n-6 FAs increased in serum triglycerides after obesity surgery (all P<0.002). Weight loss predicted changes in quantitative amounts of saturated FAs, monounsaturated FAs, n-3 and n-6 FAs in triglycerides (P<0.002 for all). Moreover, the changes in adipose tissue FAs reflected the changes in serum FAs, and some of the changes were associated with mRNA expression of elongases and desaturases in adipose tissue (all P<0.05). In line with this the estimated activity of elongase (18:1 n-7/16:1 n-7) increased significantly after obesity surgery in all lipid fractions (all P<4 × 10−7) and the increase in the estimated activity of D5D in triglycerides was associated with higher weight loss (r=0.415, P<2 × 10−6). Changes in serum FA profile were similar after obesity surgery and lifestyle intervention, except for the change in the absolute amounts of n-3 FAs between the two studies (P=0.044). Conclusions: Beneficial changes in serum and adipose tissue FAs after obesity surgery could be associated with changes in endogenous metabolism and diet.en
dc.language.isoENen
dc.publisherSpringer Natureen
dc.relation.ispartofseriesNUTRITION AND DIABETESen
dc.relation.urihttp://dx.doi.org/10.1038/nutd.2017.33en
dc.rightsCC BY http://creativecommons.org/licenses/by/4.0/en
dc.subjectFat metabolismen
dc.subjectFatty acidsen
dc.subjectObesityen
dc.titleAlterations in fatty acid metabolism in response to obesity surgery combined with dietary counselingen
dc.description.versionpublished versionen
dc.contributor.departmentSchool of Medicine / Clinical Nutritionen
dc.contributor.departmentSchool of Medicine / Clinical Medicine,School of Medicine / Biomedicineen
uef.solecris.id49363345en
dc.type.publicationinfo:eu-repo/semantics/articleen
dc.rights.accessrights© Authorsen
dc.relation.doi10.1038/nutd.2017.33en
dc.description.reviewstatuspeerRevieweden
dc.relation.articlenumbere285en
dc.relation.issn2044-4052en
dc.relation.issue9en
dc.relation.volume7en
dc.rights.accesslevelopenAccessen
dc.type.okmA1en
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
uef.solecris.openaccessOpen access -julkaisukanavassa ilmestynyt julkaisu


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