dc.contributor.author | Mardinoglu A | |
dc.contributor.author | Gogg S | |
dc.contributor.author | Lotta LA | |
dc.contributor.author | Stancáková A | |
dc.contributor.author | Nerstedt A | |
dc.contributor.author | Boren J | |
dc.contributor.author | Blüher M | |
dc.contributor.author | Ferrannini E | |
dc.contributor.author | Langenberg C | |
dc.contributor.author | Wareham NJ | |
dc.contributor.author | Laakso M | |
dc.contributor.author | Smith U | |
dc.date.accessioned | 2018-02-12T09:38:54Z | |
dc.date.available | 2018-02-12T09:38:54Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/6084 | |
dc.description.abstract | Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if 3-HIB is a marker of human IR and future risk of developing Type 2 diabetes (T2D), we measured plasma levels of 3-HIB and associated metabolites in around 10,000 extensively phenotyped individuals. The levels of 3-HIB were increased in obesity but not robustly associated with degree of IR after adjusting for BMI. Nevertheless, also after adjusting for obesity and plasma BCAA, 3-HIB levels were associated with future risk of incident T2D. We also examined the effect of 3-HIB on fatty acid uptake in human cells and found that both HUVEC and human cardiac endothelial cells respond to 3-HIB whereas human adipose tissue-derived endothelial cells do not respond to 3-HIB. In conclusion, we found that increased plasma level of 3-HIB is a marker of future risk of T2D and 3-HIB may be important for the regulation of metabolic flexibility in heart and muscles. | en |
dc.language.iso | EN | en |
dc.publisher | Elsevier BV | en |
dc.relation.ispartofseries | EBioMedicine | en |
dc.relation.uri | http://dx.doi.org/10.1016/j.ebiom.2017.12.008 | en |
dc.rights | CC BY 4.0 | |
dc.subject | 3-Hydroxyisobutyric acid (3-HIB) | en |
dc.subject | Branched-chain amino acids (BCAAs) | en |
dc.subject | T2D | en |
dc.subject | Insulin resistance | en |
dc.subject | Insulin secretion | en |
dc.title | Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes | en |
dc.description.version | published version | en |
dc.contributor.department | School of Medicine / Clinical Medicine | en |
uef.solecris.id | 52405978 | en |
dc.type.publication | info:eu-repo/semantics/article | en |
dc.relation.doi | 10.1016/j.ebiom.2017.12.008 | en |
dc.description.reviewstatus | peerReviewed | en |
dc.format.pagerange | 151-155 | en |
dc.relation.issn | 2352-3964 | en |
dc.relation.volume | 27 | en |
dc.rights.accesslevel | openAccess | en |
dc.type.okm | A1 | en |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
uef.solecris.openaccess | Open access -julkaisukanavassa ilmestynyt julkaisu | |
dc.rights.copyright | © Authors | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |