Renal Complications in COVID-19: A Systematic Review and Meta-Analysis
Self archived versionfinal draft
MetadataShow full item record
CitationKunutsor, SK. Laukkanen, JA. (2020). Renal Complications in COVID-19: A Systematic Review and Meta-Analysis. Annals of medicine, 52 (7) , 345-353. 10.1080/07853890.2020.1790643.
Emerging data suggest that coronavirus disease 2019 (COVID-19) has extrapulmonary manifestations but its renal manifestations are not clearly defined. We aimed to evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis.
Observational studies reporting renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library from 2019 to June 2020. The nine-star Newcastle-Ottawa Scale was used to evaluate methodological quality. Incidence with 95% confidence intervals (CIs) were pooled using random-effects models.
We included 22 observational cohort studies comprising of 17,391 COVID-19 patients. Quality scores of studies ranged from 4 to 6. The pooled prevalence of pre-existing chronic kidney disease (CKD) and end-stage kidney disease was 5.2% (2.8–8.1) and 2.3% (1.8–2.8), respectively. The pooled incidence over follow-up of 2–28 days was 12.5% (10.1–15.0) for electrolyte disturbance (e.g. hyperkalaemia), 11.0% (7.4–15.1) for acute kidney injury (AKI) and 6.8% (1.0–17.0) for renal replacement therapy (RRT). In subgroup analyses, there was a higher incidence of AKI in US populations and groups with higher prevalence of pre-existing CKD.
Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte disturbance, AKI and RRT. Aggressive monitoring and management of these renal complications may help in the prediction of favourable outcomes.
Subjectsrenal complications acute kidney injury COVID-19 meta-analysis
Link to the original itemhttp://dx.doi.org/10.1080/07853890.2020.1790643
PublisherInforma UK Limited
- Terveystieteiden tiedekunta