Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study

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Date
2017
Author(s)
Britton Annie R
Grobbee Diederick E
den Ruijter Hester M
Anderson Todd J
Desvarieux Moise
Engström Gunnar
Evans Greg W
Hedblad Bo
Kauhanen Jussi
Kurl Sudhir
Lonn Eva M
Mathiesen Ellisiv B
Polak Joseph F
Price Jacqueline F
Rembold Christopher M
Rosvall Maria
Rundek Tatjana
Salonen Jukka T
Stehouwer Coen
Tuomainen Tomi-Pekka et al.
Unique identifier
10.1093/alcalc/agx028
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Citation
Britton Annie R. Grobbee Diederick E. den Ruijter Hester M. Anderson Todd J. Desvarieux Moise. Engström Gunnar. Evans Greg W. Hedblad Bo. Kauhanen Jussi. Kurl Sudhir. Lonn Eva M. Mathiesen Ellisiv B. Polak Joseph F. Price Jacqueline F. Rembold Christopher M. Rosvall Maria. Rundek Tatjana. Salonen Jukka T. Stehouwer Coen. Tuomainen Tomi-Pekka et al.. (2017). Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study.  ALCOHOL AND ALCOHOLISM, 52 (4) , 483-486. 10.1093/alcalc/agx028.
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Abstract

Aims
Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population.

Methods
Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption.

Results
The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming >10 g per day, after adjusting for a range of confounding factors.

Conclusion
In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

Subjects
atherosclerosis   ethanol   alcohol drinking   linear regression   moderate drinking   heavy drinking   carotid intima-media thickness   
URI
https://erepo.uef.fi/handle/123456789/5075
Link to the original item
http://dx.doi.org/10.1093/alcalc/agx028
Publisher
Oxford University Press (OUP)
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