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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

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published version
Date
2017
Author(s)
Davis JP
Huyghe JR
Locke AE
Jackson AU
Sim X
Stringham HM
Teslovich TM
Welch RP
Fuchsberger C
Narisu N
Chines PS
Kangas AJ
Soininen P
Ala-Korpela M
Kuusisto J
Collins FS
Laakso M
Boehnke M
Mohlke KL
Unique identifier
10.1371/journal.pgen.1007079
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Citation
Davis JP. Huyghe JR. Locke AE. Jackson AU. Sim X. Stringham HM. Teslovich TM. Welch RP. Fuchsberger C. Narisu N. Chines PS. Kangas AJ. Soininen P. Ala-Korpela M. Kuusisto J. Collins FS. Laakso M. Boehnke M. Mohlke KL. (2017). Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.  PLOS GENETICS [ONLINE), 13 (10) , e1007079. 10.1371/journal.pgen.1007079.
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CC0 1.0 https://creativecommons.org/publicdomain/zero/1.0/
Abstract

Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005<minor allele frequency [MAF]<0.05) or rare (MAF<0.005) variant, including Arg123His in LCAT. Gene-based associations (P<10−10) support a role for coding variants in LIPC and LIPG with lipoprotein subclass traits. 30 established lipid-associated loci had a stronger association for a subclass trait than any conventional trait. These novel association signals provide further insight into the molecular basis of dyslipidemia and the etiology of metabolic disorders.

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https://erepo.uef.fi/handle/123456789/5773
Link to the original item
http://dx.doi.org/10.1371/journal.pgen.1007079
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Public Library of Science (PLoS)
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  • Terveystieteiden tiedekunta [1330]
University of Eastern Finland
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