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Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy

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Date
2017
Author(s)
Srivastava, Prashant K
Roncon, Paolo
Lukasiuk, Katarzyna
Gorter, Jan A
Aronica, Eleonora
Pitkänen, Asla
Petretto, Enrico
Johnson, Michael R
Simonato, Michele
Unique identifier
10.1523/ENEURO.0152-17.2017
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Research Database SoleCris

Self-archived article

Citation
Srivastava, Prashant K. Roncon, Paolo. Lukasiuk, Katarzyna. Gorter, Jan A. Aronica, Eleonora. Pitkänen, Asla. Petretto, Enrico. Johnson, Michael R. Simonato, Michele. (2017). Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy.  eNeuro, 4 (6) , 1-22. 10.1523/ENEURO.0152-17.2017.
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CC BY http://creativecommons.org/licenses/by/4.0/
Abstract

The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis, and five differentially expressed in chronic epilepsy. Of these, 13 were not identified in any of the individual studies. To assess the role of these miRNAs, we predicted their mRNA targets and then filtered the list to include only target genes expressed in DG and negatively correlated with miRNA expression. Functional enrichment analysis of mRNA targets of miRNAs dysregulated during epileptogenesis suggested a role for molecular processes related to inflammation and synaptic function. Our results identify new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta-analysis in maximizing value from preclinical data.

Subjects
dentate gyrus   epilepsy   hippocampus   meta-analysis   miRNA   mRNA   
URI
https://erepo.uef.fi/handle/123456789/6254
Link to the original item
http://dx.doi.org/10.1523/ENEURO.0152-17.2017
Publisher
Society for Neuroscience
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  • Terveystieteiden tiedekunta [1324]
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