dc.contributor.author | Gureviciene Irina | |
dc.contributor.author | Gurevicius Kestutis | |
dc.contributor.author | Mugantseva Ekaterina | |
dc.contributor.author | Kislin Mikhail | |
dc.contributor.author | Khiroug Leonard | |
dc.contributor.author | Tanila Heikki | |
dc.date.accessioned | 2020-01-08T10:40:00Z | |
dc.date.available | 2020-01-08T10:40:00Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | https://erepo.uef.fi/handle/123456789/7893 | |
dc.description.abstract | Amyloid plaques, although inducing damage to the immediately surrounding neuropil, have been proposed to provide a relatively innocuous way to deposit toxic soluble amyloid-β (Aβ) species. Here we address this hypothesis by exploring spread and absorption of fluorescent Aβ to pre-existing amyloid plaques after local application in wild-type mice versus APP/PS1 transgenic mice with amyloid plaques. Local intracortical or intracerebroventricular injection of fluorescently-labeled Aβ in APP/PS1 mice with a high plaque density resulted in preferential accumulation of the peptide in amyloid plaques in both conventional postmortem histology and in live imaging using two-photon microscopy. These findings support the contention that amyloid plaques may act as buffers to protect neurons from the toxic effects of momentary high concentrations of soluble Aβ oligomers. | |
dc.language.iso | englanti | |
dc.publisher | IOS Press | |
dc.relation.ispartofseries | Journal of Alzheimer's Disease | |
dc.relation.uri | http://dx.doi.org/10.3233/JAD-160453 | |
dc.rights | In copyright 1.0 | |
dc.subject | alzheimer’s disease | |
dc.subject | amyloid-β | |
dc.subject | in vivo imaging | |
dc.subject | multiphoton | |
dc.subject | transgenic | |
dc.title | Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-ß | |
dc.description.version | final draft | |
dc.contributor.department | A.I. Virtanen -instituutti / Neurobiologia | |
uef.solecris.id | 43273215 | en |
dc.type.publication | Tieteelliset aikakauslehtiartikkelit | |
dc.relation.doi | 10.3233/JAD-160453 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 147-157 | |
dc.publisher.country | Alankomaat | |
dc.relation.issn | 1387-2877 | |
dc.relation.issue | 1 | |
dc.relation.volume | 55 | |
dc.rights.accesslevel | openAccess | |
dc.type.okm | A1 | |
uef.solecris.openaccess | Ei | |
dc.rights.copyright | © IOS Press and the authors | |
dc.type.displayType | article | en |
dc.type.displayType | artikkeli | fi |
dc.rights.url | https://rightsstatements.org/page/InC/1.0/ | |