Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood
Self archived versionfinal draft
MetadataShow full item record
CitationMäntyselkä, A. Haapala, EA. Lindi, V. Häkkinen, MR. Auriola, S. Jääskeläinen, J. Lakka, TA. (2019). Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. Hormone research in paediatrics, 91, 329–335. 10.1159/000501719.
Background: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical signs of androgen action were evaluated. Results: Higher IGF-1 among boys (β = 0.149, p =0.033) was related to a better Raven’s CPM score after adjustment for age and parental education. Adrenal androgens in girls or boys or IGF-1 in girls were not associated with the score. There were no differences in Raven’s CPM score between children with biochemical adrenarche (DHEAS ≥1.08 µmol/L; ≥40 µg/dL) or with clinical signs of androgen action and children without them. Conclusion: The results suggest that higher serum IGF-1 among boys is related to better cognition in prepubertal children. We could not provide evidence for the associations of adrenal maturation with cognition in prepubertal children.
Link to the original itemhttp://dx.doi.org/10.1159/000501719
- Terveystieteiden tiedekunta