Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men
Self archived versionPublisher's pdf
MetadataShow full item record
CitationVirtanen JK. Giniatullin R. Mäntyselkä P. Voutilainen S. Nurmi T. Mursu J. Kauhanen J. Tuomainen TP. (2017). Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men. Scientific Reports, 7, 39697. 10.1038/srep39697.
Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42–60 years in 1984–1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8–136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men.
Link to the original itemhttp://doi.org/10.1038/srep39697
- Terveystieteiden tiedekunta