MB-SWIFT functional MRI during deep brain stimulation in rats
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CitationLehto Lauri J. Idiyatullin Djaudat. Zhang Jinjin. Utecht Lynn. Adriany Gregor. Garwood Michael. Gröhn Olli. Michaeli Shalom. Mangia Silvia. (2017). MB-SWIFT functional MRI during deep brain stimulation in rats. NEUROIMAGE, 159, 443-448. 10.1016/j.neuroimage.2017.08.012.
Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having virtually zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 T during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows functional images free of susceptibility artifacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast. MB-SWIFT fMRI modality permits activation studies in the close proximity to an implanted lead, which is not possible to achieve with conventionally used gradient echo and spin echo - echo planar imaging fMRI techniques. We conclude that MB-SWIFT fMRI is a powerful imaging modality for investigations of functional responses during DBS.
SubjectsMulti-band SWIFT fMRI Zero-TE fMRI Blood flow Deep brain stimulation
Link to the original itemhttp://dx.doi.org/10.1016/j.neuroimage.2017.08.012
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