Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

CSF nerve growth factor (ß-NGF) is increased but CSF insulin-like growth factor-(IGF-1) is normal in children with tuberous sclerosis and infantile spasms

Thumbnail
Files
Article (801.1Kb)
Self archived version
final draft
Date
2019
Author(s)
Riikonen, Raili
Kokki, Hannu
Unique identifier
10.1016/j.ejpn.2018.11.001
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Riikonen, Raili. Kokki, Hannu. (2019). CSF nerve growth factor (ß-NGF) is increased but CSF insulin-like growth factor-(IGF-1) is normal in children with tuberous sclerosis and infantile spasms.  EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 23 (1) , 191-196. 10.1016/j.ejpn.2018.11.001.
Rights
© Elsevier Ltd on behalf of European Paediatric Neurology Society.
Licensed under
CC BY-NC-ND https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Tuberous sclerosis is associated with epilepsy that is often refractory. We examined cerebrospinal fluid (CSF) concentrations for neurotrophins, nerve growth factor (β-NGF) and insulin-like growth factor (IGF-1) in children with infantile spasms between 1997 and 2010. We classified the patients as follows: tuberous sclerosis (n = 5), cryptogenic spasms (n = 6), postinfectious spasms (n = 5) and other symptomatic spasms (n = 22). We had 22 age- and sex-matched controls for CSF-NGF and 14 for CSF-IGF-1. The median of CSF-NGF was higher in those with tuberous sclerosis, 56 (minimum–maximum, 8.0–131) ng/L, in relative to age- and sex-matched controls, 6.7 (0.0–22) ng/L, and symptomatic infantile spasms, 0.0 (0.0–4.5) ng/L or cryptogenic cases of infantile spasms, 6.2 (3.9–8.8) ng/L, respectively. CSF-NGF were highest in children with postinfectious aetiology, 408 (89–778) ng/L. CSF-IGF-1 of tuberous sclerosis, 0.65 (0.35–0.98) μg/L, did not differ from the cryptogenic spasms, 0.68 (0.32–0.87) μg/L, or from age- and sex-matched controls 0.52 (0.22–0.77) μg/L. Patients with tuberous sclerosis and cryptogenic spasms had normal development prior the ACTH therapy. We suggest that increased CSF-NGF might indicate a persistent activation of inflammatory pathways in cortical tubers in tuberous sclerosis and this would reflect in CSF concentrations.

Subjects
tuberous sclerosis   nerve growth facto   insulin-like growth factor   infantile spasms   
URI
https://erepo.uef.fi/handle/123456789/7353
Link to the original item
http://dx.doi.org/10.1016/j.ejpn.2018.11.001
Publisher
Elsevier BV
Collections
  • Terveystieteiden tiedekunta [1324]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
OpenUEF
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap