Skip to main contentSkip to search and navigation

UEF eREPOSITORY

    • English
    • suomi
  • English 
    • English
    • suomi
  • Login
View Item 
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
  •   Home
  • Artikkelit
  • Terveystieteiden tiedekunta
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma

Thumbnail
Files
Article (3.133Mb)
Self archived version
final draft
Date
2019
Author(s)
Mustonen, Anne-Mari
Salvén, Anu
Kärjä, Vesa
Rilla, Kirsi
Matilainen, Johanna
Nieminen, Petteri
Unique identifier
10.1093/glycob/cwz002
Metadata
Show full item record
More information
Research Database SoleCris

Self-archived article

Citation
Mustonen, Anne-Mari. Salvén, Anu. Kärjä, Vesa. Rilla, Kirsi. Matilainen, Johanna. Nieminen, Petteri. (2019). Hyaluronan histochemistry - A potential new tool to assess the progress of liver disease from simple steatosis to hepatocellular carcinoma.  Glycobiology, 29 (4) , 298-306. 10.1093/glycob/cwz002.
Rights
© Authors
Licensed under
All rights reserved
Abstract

Nonalcoholic fatty liver disease is among the most common liver diseases worldwide and one cause of cirrhosis that can result in the development of hepatocellular carcinoma (HCC). Hyaluronan (HA) is a high-molecular-mass glycosaminoglycan with diverse functions in tissue injury and repair, for instance, in inflammation and fibrogenesis. The aim of the present study was to investigate the relationships between the HA synthesizing and degrading enzymes in a spectrum of liver pathologies. This was realized by histological staining of liver sections from controls and patients with simple steatosis, steatohepatitis, cirrhosis and HCC (n = 90). HA-positive staining intensified in connective tissue in all liver pathologies, and staining of CD44, the major HA receptor, similarly increased in steatohepatitis and cirrhosis. HA synthase 1 (HAS1)-positive staining was reduced in steatosis, steatohepatitis and HCC. Staining of HAS3, which produces HA of a lower molecular mass, promotes inflammation and is pathogenic in animal models, increased in all diagnoses. The responses in staining intensity of HAS2 and hyaluronidases 1–2 were specific for different cell types. These findings suggest that HAS1–2 are responsible for HA synthesis in healthy livers, while HAS3 increases in importance in liver diseases. It is noteworthy that the pathological changes in HA metabolism are already visible in simple steatosis and, thus, precede the histological changes of inflammation and fibrosis. It could be possible to intervene in disease progression at an early stage by influencing HA metabolism. The results could have potential clinical applications with HAS3 immunostaining supplementing the existing HCC diagnostics.

Subjects
cirrhosis   hepatocellular carcinoma   hyaluronan   nonalcoholic fatty liver disease   nonalcoholic steatohepatitis   
URI
https://erepo.uef.fi/handle/123456789/7555
Link to the original item
http://dx.doi.org/10.1093/glycob/cwz002
Publisher
Oxford University Press (OUP)
Collections
  • Terveystieteiden tiedekunta [1330]
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap
Search

Browse

All of the ArchiveResource types & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subjectThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDepartmentFull organizationSeriesMain subject

My Account

Login
University of Eastern Finland
OpenAccess
eRepo
erepo@uef.fi
UEF Open Science
Accessibility in eRepo
Service provided by
the University of Eastern Finland Library
Library web pages
Twitter
Facebook
Youtube
Library blog
 sitemap