Browsing Terveystieteiden tiedekunta by Title
Now showing items 1670-1689 of 1735
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UDP-sugar accumulation drives hyaluronan synthesis in breast cancer
(Elsevier BV, 2018)Increased uptake of glucose, a general hallmark of malignant tumors, leads to an accumulation of intermediate metabolites of glycolysis. We investigated whether the high supply of these intermediates promotes their flow ...Tieteelliset aikakauslehtiartikkelit
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Underlying and immediate causes of death in patients with idiopathic pulmonary fibrosis
(Springer Nature, 2018)Background The most common cause of death of patients with idiopathic pulmonary fibrosis (IPF) has been reported to be the lung disease itself and mortality from IPF appears to be increasing. However, the causes of death ...Tieteelliset aikakauslehtiartikkelit
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Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations
(Elsevier, 2022)Rapid precorneal loss of topically applied eye drops limits ocular drug absorption. Controlling release and precorneal residence properties of topical formulations may improve ocular drug bioavailability and duration of ...
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Unraveling the complex story of immune responses to AAV vectors trial after trial
(Mary Ann Liebert Inc, 2017)Over the past decade, vectors derived from adeno-associated virus (AAV) have established themselves as a powerful tool for in vivo gene transfer, allowing long-lasting and safe transgene expression in a variety of human ...info:eu-repo/semantics/article
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Up-regulation of Mismatch Repair Pathway by Suicide Gene Therapy: Implications on the use of Temozolomide Treatment in Malignant Glioma
(OMICS Publishing Group, 2018)Objective: The dependency of the efficacy of temozolomide (TMZ) on cellular DNA repair activities makes it therapeutically effective in approximately half of malignant glioma (MG) patient population with a dysfunctional ...Tieteelliset aikakauslehtiartikkelit
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Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations
(Springer Nature, 2017)Many Lynch syndrome (LS) carriers remain unidentified, thus missing early cancer detection and prevention opportunities. Tested probands should inform their relatives about cancer risk and options for genetic counselling ...info:eu-repo/semantics/article
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Usage and Dose Response of a Mobile Acceptance and Commitment Therapy App: Secondary Analysis of the Intervention Arm of a Randomized Controlled Trial
(JMIR Publications Inc, 2016)Background: Mobile phone apps offer a promising medium to deliver psychological interventions. A mobile app based on Acceptance and Commitment Therapy (ACT) was developed and studied in a randomized controlled trial ...info:eu-repo/semantics/article
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Use of coercion prevention tools in Finnish psychiatric wards
(Elsevier BV, 2020)Inpatient violence is a widespread problem in psychiatric wards and has often serious consequences. Literature indicates that de-escalation techniques are the recommended first-line intervention for managing violence, are ...Tieteelliset aikakauslehtiartikkelit
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Use of Health Registers
(Springer Nature, 2022)Routine data are data collected continuously or at least repeatedly with some time intervals. They are collected in various ways, e.g., registration by the health services or by interviews with patients or population groups. ...
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Use of oral health care services in Finnish adults - results from the cross-sectional Health 2000 and 2011 Surveys
(Springer Nature, 2017)Background During the 2000s, two major legislative reforms concerning oral health care have been implemented in Finland. One entitled the whole population to subsidized care and the other regulated the timeframes of access ...info:eu-repo/semantics/article
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Use of paclitaxcel-coated balloons in clinical setting is not associated with increased mortality compared to plain balloon angioplasty in femoropopliteal lesions
(Elsevier Inc., 2022)Objective To investigate mortality and causes of death associated with the use of paclitaxel-coated balloon (PCB) compared with plain balloon (PB) angioplasty in the treatment of femoropopliteal artery lesions in real-world ...
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Usefulness of neuron specific enolase in prognostication after cardiac arrest: Impact of age and time to ROSC
(Elsevier BV, 2019)Aim of the study We evaluated the impact of patient age and time from collapse to return of spontaneous circulation (ROSC) on the prognostic accuracy of neuron specific enolase (NSE) after out-of-hospital cardiac arrest ...Tieteelliset aikakauslehtiartikkelit
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Using a cross-contextual reciprocal learning approach in a multisite implementation research project to improve self-management for type 2 diabetes
(BMJ Publishing Group Ltd, 2018)This paper reports on the use of reciprocal learning for identifying, adopting and adapting a type 2 diabetes self-management support intervention in a multisite implementation trial conducted in a rural setting in a ...Tieteelliset aikakauslehtiartikkelit
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Uusi geenihoito tulossa uusiutuneen hoitoresistentin akuutin lymfoblastileukemian hoitoon
(Suomalainen lääkäriseura Duodecim, 2018)article
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UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
(Association for Research in Vision and Ophthalmology (ARVO), 2020)Purpose: The cornea is continually exposed to highly energetic solar UV-B (280-320 nm). Our aim was to investigate whether UV-B triggers the activation of NLRP3 inflammasomes and the production of IL-1β and/or IL-18 in ...Tieteelliset aikakauslehtiartikkelit
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Vaarallisuuden arviointi - sattuman summaako?
(Edita Publishing Oy, 2020)Artikkeli on kirjallisuuskatsaus vaarallisuuden ja väkivaltariskin arviointimenetelmistä ja niiden käyttökelpoisuudesta oikeuspsykiatrisen tehtäväalueen ja oikeuslaitoksen tarpeisiin. Lisäksi artikkelissa pohditaan ja ...Tieteelliset aikakauslehtiartikkelit
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Vakavasti sairaan aikuispotilaan tehohoidon rajaaminen
(Suomalainen lääkäriseura Duodecim, 2022)COVID-19-pandemia on aiheuttanut ympäri maailmaa ja Suomessakin runsaasti huolta tehohoidon kapasiteetin riittävyydestä niin tautiin vakavasti sairastuneille kuin muillekin tehohoitoa tarvitseville potilaille. Potilaiden ...
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Vakavien syiden ilmaantuvuus atraumaattisen alaselkäkivun taustalla erikoissairaanhoidon päivystyksessä
(Suomen ortopediayhdistys ry, 2017)info:eu-repo/semantics/article
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Validation of biomarkers of food intake - critical assessment of candidate biomarkers
(Springer Nature, 2018)Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary ...Tieteelliset aikakauslehtiartikkelit
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Validation of protein carbonyl measurement: A multi-centre
(Elsevier BV, 2014)Protein carbonyls are widely analysed as a measure of protein oxidation. Several different methods exist for their determination. A previous study had described orders of magnitude variance that existed when protein carbonyls ...info:eu-repo/semantics/article