Browsing Terveystieteiden tiedekunta by Title
Now showing items 286-305 of 1735
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Chloropicrin-induced toxicity in the respiratory system
(Elsevier BV, 2020)Chloropicrin is a volatile and reactive chemical that has been utilized as a warfare agent and a pesticide to fumigate soil against insects, fungi and nematodes. It poses a health risk to humans and animals if inhaled. The ...Tieteelliset aikakauslehtiartikkelit
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Cholinergic Nociceptive Mechanisms in Rat Meninges and Trigeminal Ganglia: Potential Implications for Migraine Pain
(Frontiers Media SA, 2017)Background: Parasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches suggests contribution of cholinergic mechanisms to primary headaches. However, ...info:eu-repo/semantics/article
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Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans
(Elsevier BV, 2017)Methylmercury (MeHg) is a persistent environmental pollutant that occurs in the food chain, at occupational sites, and via medical procedures. Exposure in humans and animal models results in renal, neuro, and reproductive ...info:eu-repo/semantics/article
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Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice
(Frontiers Research Foundation, 2016)Numerous studies have reported neuroprotective effects of pyruvate when given in systemic injections. Impaired glucose uptake and metabolism are found in Alzheimer’s disease (AD) and in AD mouse models. We tested whether ...info:eu-repo/semantics/article
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Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury
(Public Library of Science (PLoS), 2017)Traumatic brain injury (TBI) can result in several dentate gyrus-regulated disabilities. Almost nothing is known about the chronic molecular changes after TBI, and their potential as treatment targets. We hypothesized that ...info:eu-repo/semantics/article
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Chronotropic Response to Exercise Testing and the Risk of Stroke
(Elsevier BV, 2021)Although the chronotropic response to exercise testing, defined as an inadequate heart rate response to incremental exercise to volitional fatigue, is associated with adverse cardiovascular outcomes, it remains unclear ...Tieteelliset aikakauslehtiartikkelit
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Circulating Basophils as a Prognostic Marker for Response to Bacillus Calmette-Guérin
(Elsevier Inc, 2024)Purpose To predict recurrence and progression in non–muscle-invasive bladder cancer (NMIBC) patients receiving bacillus Calmette-Guérin (BCG), we evaluated circulating basophils as a biomarker that could be detected from ...
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Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodi
(American Diabetes Association, 2017)Although type 1 diabetes (T1D) is primarily perceived as a T-cell-driven autoimmune disease, islet autoantibodies are the best currently available biomarker for autoimmunity and disease risk. These antibodies are produced ...info:eu-repo/semantics/article
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Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock
(Wiley, 2019)Aims The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR‐423‐5p level to predict mortality and associations of miR‐423‐5p with prognostic markers in cardiogenic ...Tieteelliset aikakauslehtiartikkelit
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Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
(Springer Nature America, Inc, 2018)Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent ...Tieteelliset aikakauslehtiartikkelit
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Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model
(Mary Ann Liebert Inc, 2021)Based on recent success in using modified RNA in clinical applications, we tested the safety, feasibility, and efficacy of direct delivery of citrate-saline-formulated mRNA into an hibernating ischemic heart muscle using ...Tieteelliset aikakauslehtiartikkelit
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Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
(Wiley, 2020)Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) ...Tieteelliset aikakauslehtiartikkelit
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Climate change and epilepsy: Insights from clinical and basic science studies
(Elsevier BV, 2021)Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global ...Tieteelliset aikakauslehtiartikkelit
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Clinical deep brain stimulation strategies for orientation-selective pathway activation
(IOP Publishing, 2018)Objective. This study investigated stimulation strategies to increase the selectivity of activating axonal pathways within the brain based on their orientations relative to clinical deep brain stimulation (DBS) lead implants. ...Tieteelliset aikakauslehtiartikkelit
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Clinical disease presentation and ECG characteristics of LMNA mutation carriers
(2017)Objective Mutations in the LMNA gene encoding lamins A and C of the nuclear lamina are a frequent cause of cardiomyopathy accounting for 5–8% of familial dilated cardiomyopathy (DCM). Our aim was to study disease onset, ...info:eu-repo/semantics/article
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Clinical features of Parkinson's disease patients are associated with therapeutic misconception and willingness to participate in clinical trials
(Springer Nature, 2017)Background Clinical trials (CTs) are the “gold standard” to ensure the development of new effective treatments in medicine. A study was conducted to assess knowledge of, and attitudes toward, clinical trials among patients ...info:eu-repo/semantics/article
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Clinical Nurse Specialist Role Implementation Structures, Processes and Outcomes: Participatory Action Research
(Wiley, 2021)Aim To develop, implement and evaluate the clinical nurse specialist's role within a specialist medical healthcare hospital. A secondary aim was to assess the feasibility of the ‘Clinical Nurse Specialist Conceptualisation, ...Tieteelliset aikakauslehtiartikkelit
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Closing Finnish schools and day care centres had a greater impact on primary care than secondary care emergency department visits
(Wiley, 2021)Tieteelliset aikakauslehtiartikkelit
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Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study
(2017)Background The relation of a single risk factor with atherosclerosis is established. Clinically we know of risk factor clustering within individuals. Yet, studies into the magnitude of the relation of risk factor clusters ...info:eu-repo/semantics/article
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Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs
(MDPI AG, 2021)In this study, the amino acid arginine (ARG) and P-glycoprotein (P-gp) inhibitors verapamil hydrochloride (VER), piperine (PIP) and quercetin (QRT) were used as co-formers for co-amorphous mixtures of a Biopharmaceutics ...Tieteelliset aikakauslehtiartikkelit