Browsing Terveystieteiden tiedekunta by Title
Now showing items 387-406 of 1735
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Current Situation and Challenges in Vitreous Substitutes
(Wiley, 2021)Vitreo-retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo-retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous ...Tieteelliset aikakauslehtiartikkelit
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Curricula Challenges and Informatics Competencies for Nurse Educators
(IOS Press, 2017)Nursing informatics competencies are fundamental to nursing practice in all areas of nursing work, including direct patient care, administration and education. The recent activity relating to the development of nursing ...info:eu-repo/semantics/bookPart
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Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells
(American Society for Cell Biology (ASCB), 2015)Contrary to cell cycle–associated cyclin-dependent kinases, CDK5 is best known for its regulation of signaling processes in differentiated cells and its destructive activation in Alzheimer's disease. Recently, CDK5 has ...info:eu-repo/semantics/article
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Cyclodextrin-based organic radical contrast agents for in vivo imaging of glioma
(Wiley, 2020)Cyclodextrins (CDs), a class of cyclic oligosaccharides formed by α‐(1,4) linked glucopyranose units, were functionalized with (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) radicals to prepare water soluble supramolecular ...Tieteelliset aikakauslehtiartikkelit
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Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors
(Public Library of Science (PLoS), 2017)Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the role of a reactive cysteine residue, Cys-893, in the cytosolic ...info:eu-repo/semantics/article
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Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach
(Springer, 2016)Background and Objectives Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater ...info:eu-repo/semantics/article
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DAPI (4’,6-diamidino-2-phenylindole) Stains Compact Amyloid Plaques
(IOS Press., 2022)DAPI is conventionally used as a nuclear stain for cells in culture or tissue. Here we demonstrate that it binds specifically to the β-sheet core of amyloid-β plaques but not diffuse amyloid-β at the plaque periphery. The ...
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Dark chocolate and reduced snack consumption in mildly hypertensive adults: an intervention study
(BioMed Central, 2015)Background Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate ...info:eu-repo/semantics/article
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Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase
(Elsevier Inc., 2016)Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes, IN [1] and RT [2]. Herein, we present chemical synthesis of ...info:eu-repo/semantics/article
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Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier
(Frontiers Media SA, 2018)Clinical decision support systems (CDSSs) hold potential for the differential diagnosis of neurodegenerative diseases. We developed a novel CDSS, the PredictND tool, designed for differential diagnosis of different types ...Tieteelliset aikakauslehtiartikkelit
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Data-Driven Identification of Long-Term Glycemia Clusters and Their Individualized Predictors in Finnish Patients with Type 2 Diabetes
(Dove Press Ltd, 2023)Purpose: To gain an understanding of the heterogeneous group of type 2 diabetes (T2D) patients, we aimed to identify patients with the homogenous long-term HbA1c trajectories and to predict the trajectory membership for ...
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Data-driven long-term glycaemic control trajectories and their associated health and economic outcomes in Finnish patients with incident type 2 diabetes
(Public Library of Science, 2022)Background Treatments should be customized to patients to improve patients’ health outcomes and maximize the treatment benefits. We aimed to identify meaningful data-driven trajectories of incident type 2 diabetes patients ...
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Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma
(BioMed Central Ltd., 2016)Background Hyaluronan is a large extracellular matrix molecule involved in several biological processes such as proliferation, migration and invasion. In many cancers, hyaluronan synthesis is altered, which implicates ...info:eu-repo/semantics/article
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Decreased plasma C-reactive protein levels in APOE E 4 allele carriers
(Wiley, 2018)Objective Apolipoprotein E (APOE) ε4 allele is a well‐established risk factor in Alzheimer's disease (AD). Here, we assessed the effects of APOE polymorphism on cardiovascular, metabolic, and inflammation‐related parameters ...Tieteelliset aikakauslehtiartikkelit
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DeepCDA: Deep Cross-Domain Compound-Protein Affinity Prediction through LSTM and Convolutional Neural Networks
(Oxford University Press (OUP), 2020)Motivation An essential part of drug discovery is the accurate prediction of the binding affinity of new compound–protein pairs. Most of the standard computational methods assume that compounds or proteins of the test ...Tieteelliset aikakauslehtiartikkelit
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Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility
(Elsevier BV, 2019)Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the cerebral cortex and tissue remodeling ...Tieteelliset aikakauslehtiartikkelit
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Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
(Elsevier BV, 2021)Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid ...Tieteelliset aikakauslehtiartikkelit
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Defining Terms Used for Animals Working in Support Roles for People with Support Needs
(MDPI, 2022)The nomenclature used to describe animals working in roles supporting people can be confusing. The same term may be used to describe different roles, or two terms may mean the same thing. This confusion is evident among ...
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Defining the risk factors for acute, subacute and chronic cough: a cross-sectional study in a Finnish adult employee population .
(BMJ, 2018)Objectives Chronic cough is linked to various long-standing risk factors like asthma, chronic rhinitis and oesophageal reflux disease. On the contrary, acute and subacute cough are usually considered to be caused by acute ...Tieteelliset aikakauslehtiartikkelit
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Delayed, distant skin lesions after transcranial direct current stimulation
(Elsevier BV, 2018)Tieteelliset aikakauslehtiartikkelit