Browsing Terveystieteiden tiedekunta by Title

Now showing items 1075-1094 of 1735

    • A Multi-Cohort Study of ApoE e4 and Amyloid-ß Effects on the Hippocampus in Alzheimer's Disease 

      Khan W; Giampietro V; Banaschewski T; Barker GJ; Bokde ALW; Büchel C; Conrod P; Flor H; Frouin V; Garavan H; Gowland P; Heinz A; Ittermann B; Lemaître H; Nees F; Paus T; Pausova Z; Rietschel M; Smolka MN; Ströhle A et al. (IOS Press, 2017)
      The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer’s disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), ...
      info:eu-repo/semantics/article

    • Multi-omics analysis of ten carbon nanomaterials effects highlights cell type specific patterns of molecular regulation and adaptation 

      Scala, Giovanni; Kinaret, Pia; Marwah, Veer; Sund, Jukka; Fortino, Vittorio; Greco, Dario (Elsevier BV, 2018)
      New strategies to characterize the effects of engineered nanomaterials (ENMs) based on omics technologies are emerging. However, given the intricate interplay of multiple regulatory layers, the study of a single molecular ...
      Tieteelliset aikakauslehtiartikkelit

    • Multi-Target Approach for Drug Discovery against Schizophrenia 

      Kondej, M; Stepnicki, P; Kaczor, AA (MDPI AG, 2018)
      Polypharmacology is nowadays considered an increasingly crucial aspect in discovering new drugs as a number of original single-target drugs have been performing far behind expectations during the last ten years. In this ...
      Tieteelliset aikakauslehtiartikkelit

    • Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial 

      Rosenberg, A; Ngandu, T; Rusanen, M; Antikainen, R; Bäckman, L; Havulinna, S; Hänninen, T; Laatikainen, T; Lehtisalo, J; Levälahti, E; Lindström, J; Paajanen, T; Peltonen, M; Soininen, H; Stigsdotter-Neely, A; Strandberg, T; Tuomilehto, J; Solomon, A; Kivipelto, M (Elsevier BV, 2018)
      Introduction The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We ...
      Tieteelliset aikakauslehtiartikkelit

    • Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo 

      Sarin Jaakko Kalevi; Brommer Harold; Argüelles David; Puhakka Pia Henriikka; Inkinen Satu Irene; Afara Isaac Oluwaseun; Saarakkala Simo; Töyräs Juha (2017)
      Objective We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare ...
      info:eu-repo/semantics/article

    • Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS). 

      Palmer K; Marengoni A; Forjaz MJ; Jureviciene E; Laatikainen T; Mammarella F; Muth C; Navickas R; Prados-Torres A; Rijken M; Rothe U; Souchet L; Valderas J; Vontetsianos T; Zaletel J; Onder G (Elsevier BV, 2018)
      Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful ...
      info:eu-repo/semantics/article

    • Multiplex eukaryotic transcription (in)activation : timing, bursting and cycling of a ratchet clock mechanism 

      Rybakova, Katja N; Bruggeman, Frank J; Tomaszewska, Aleksandra; Moné, Martijn J; Carlberg, Carsten; Westerhoff, Hans V (Public Library of Science (PLoS), 2015)
      Activation of eukaryotic transcription is an intricate process that relies on a multitude of regulatory proteins forming complexes on chromatin. Chromatin modifications appear to play a guiding role in protein-complex ...
      info:eu-repo/semantics/article

    • Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration 

      Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J (IOS Press, 2019)
      A lot of effort has been done to unravel the genetics underlying early-onset Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). However, many familial early-onset dementia (EOD) cases still show an ...
      Tieteelliset aikakauslehtiartikkelit

    • Mutation of TP53, translocation analysis and immunohistochemical expression of MYC, BCL-2 and BCL-6 in patients with DLBCL treated with R-CHOP 

      Peroja, P; Pedersen, M; Mantere, T; Nørgaard, P; Peltonen, J; Haapasaari, KM; Böhm, J; Jantunen, E; Turpeenniemi-Hujanen, T; Rapakko, K; Karihtala, P; Soini, Y; Vasala, K; Kuittinen, O (Springer Nature America, Inc, 2018)
      Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with diverse outcomes. Concurrent translocation of MYC and BCL-2 and/or BCL-6, and concurrent immunohistochemical (IHC) high expression of MYC and BCL-2, have ...
      Tieteelliset aikakauslehtiartikkelit

    • Myelodysplastinen oireyhtymä - monimuotoinen kirjo verisairauksia 

      Kauppila, Marjut; Holopainen, Annasofia; Kontro, Mika; Kytölä, Sari; Lehto, Minna; Laine, Outi; Myllymäki, Mikko; Rounioja, Samuli; Siitonen, Timo; Ebeling, Freja (Suomalainen lääkäriseura Duodecim, 2023)
      Myelodysplastisissa oireyhtymissä (MDS) luuytimen verisolujen tuotanto on tehotonta ja verisolujen määrä vähenee. Yleisin verenkuvalöydös on normo- tai makrosyyttinen anemia. Taudilla on alttius muuttua leukemiaksi. Diagnoosi ...

    • Myo- and cardiotoxic effects of the wild winter mushroom ( Flammulina velutipes) on mice 

      Mustonen, AM; Määttänen, M; Kärjä, V; Puukka, K; Aho, J; Saarela, S; Nieminen, P (SAGE Publications, 2018)
      Rhabdomyolysis (destruction of striated muscle) is a novel form of mushroom poisoning in Europe and Asia indicated by increased circulating creatine kinase levels. Particular wild fungi have also been reported to induce ...
      Tieteelliset aikakauslehtiartikkelit

    • NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects 

      Sliz, Eeva; Sebert, Sylvain; Würtz, Peter; Kangas, Antti J; Soininen, Pasi; Lehtimäki, Terho; Kähönen, Mika; Viikari, Jorma; Männikkö, Minna; Ala-Korpela, Mika; Raitakari, Olli T; Kettunen, Johannes (Oxford University Press (OUP), 2018)
      Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver-related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic ...
      Tieteelliset aikakauslehtiartikkelit

    • Nano-enabled strategies to combat methicillin-resistant Staphylococcus aureus 

      Singh, Sima; Numan, Arshid; Somaily, Hamoud H.; Gorain, Bapi; Ranjan, Sanjeev; Rilla, Kirsi; Siddique, Hifzur R.; Kesharwani, Prashant (Elsevier BV, 2021)
      The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a threat to global health because of limited treatments. MRSA infections are difficult to treat due to increasingly developing resistance in ...
      Tieteelliset aikakauslehtiartikkelit

    • Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems 

      Laurén P; Somersalo P; Pitkänen I; Lou YR; Urtti A; Partanen J; Seppälä J; Madetoja M; Laaksonen T; Mäkitie A; Yliperttula M (Public Library of Science (PLoS), 2017)
      Hydrogel nanomaterials, especially those that are of non-human and non-animal origins, have great potential in biomedical and pharmaceutical sciences due to their versatility and inherent soft-tissue like properties. With ...
      info:eu-repo/semantics/article

    • National Current Care Guidelines for paediatric lower respiratory tract infections reduced the use of chest radiographs but local variations were observed 

      Poutanen, Roope; Virta, Tuija; Heikkilä, Paula; Pauniaho, Satu-Liisa; Csonka, Peter; Korppi, Matti; Renko, Marjo; Palmu, Sauli (Wiley, 2021)
      Aim Our aim was to evaluate the impact of the 2014 Finnish Current Care Guidelines for paediatric lower respiratory tract infections (LRTIs), particularly on taking of chest radiographs. Methods This study used official ...
      Tieteelliset aikakauslehtiartikkelit

    • Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis 

      Natriuretic Peptides Studies Collaboration; Willeit P; Kaptoge S; Welsh P; Butterworth AS; Chowdhury R; Spackman SA; Pennells L; Gao P; Burgess S; Freitag DF; Sweeting M; Wood AM; Cook NR; Judd S; Trompet S; Nambi V; Olsen MH; Everett BM; Kee F et al. (Elsevier BV, 2016)
      Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) ...
      info:eu-repo/semantics/article

    • Natural polyphenols as sirtuin 6 modulators 

      Rahnasto-Rilla, M; Tyni, J; Huovinen, M; Jarho, E; Kulikowicz, T; Ravichandran, S; Bohr, VA; Ferrucci, L; Lahtela-Kakkonen, M; Moaddel R (Springer Nature, 2018)
      Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with various pharmacological effects. Due to their plethora of biological activities, they have been studied extensively in drug development. ...
      Tieteelliset aikakauslehtiartikkelit

    • NDUFA1 p.Gly32Arg variant in early-onset dementia 

      Huttula, Samuli; Väyrynen, Henri; Helisalmi, Seppo; Kytövuori, Laura; Luukkainen, Laura; Hiltunen, Mikko; Remes, Anne M; Krüger, Johanna (Elsevier Inc., 2022)
      Early-onset dementia (EOD) is highly heritable. However, in many EOD cases the genetic etiology remains unknown. Mitochondrial dysfunction is associated with neurodegeneration and the complex I (CI) deficiency is the most ...

    • Network analysis of impulse dyscontrol in mild cognitive impairment and subjective cognitive decline 

      Saari, T; Smith, EE; Ismail, Z (Cambridge University Press (CUP), 2021)
      Objectives: To investigate conditional dependence relationships of impulse dyscontrol symptoms in mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Design: A prospective, observational ...
      Tieteelliset aikakauslehtiartikkelit

    • Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells 

      Ghosh, Arindam; Som, Anup (Elsevier B.V, 2024)
      Growing evidence has shown that besides the protein coding genes, the non-coding elements of the genome are indispensable for maintaining the property of self-renewal in human embryonic stem cells and in cell fate ...