Browsing Terveystieteiden tiedekunta by Title
Now showing items 309-328 of 1735
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Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution
(Oxford University Press (OUP), 2019)Integration of genome-wide association study (GWAS) signals with expression quantitative trait loci (eQTL) studies enables identification of candidate genes. However, evaluating whether nearby signals may share causal ...Tieteelliset aikakauslehtiartikkelit
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Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
(Springer Nature, 2017)Background We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. Methods The cohort ...info:eu-repo/semantics/article
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Combined Effect of Sauna Bathing and Cardiorespiratory Fitness on the Risk of Sudden Cardiac Deaths in Caucasian Men: A Long-term Prospective Cohort Study
(Elsevier BV, 2018)Both cardiorespiratory fitness (CRF) and frequency of sauna bathing (FSB) are each strongly and independently associated with sudden cardiac death (SCD) risk. However, the combined effect of CRF and FSB on SCD risk has not ...Tieteelliset aikakauslehtiartikkelit
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Combined Low-Dose Zearalenone and Aflatoxin B1 on Cell Growth and Cell-Cycle Progression in Breast Cancer MCF-7 Cells
(Elsevier BV, 2017)Zearalenone (ZEA) has long been recognized as a xenoestrogen, while the endocrine disrupting effects of aflatoxin B1 (AFB1) have been identified recently. Due to co-occurrence and endocrine disrupting potentials of ZEA and ...info:eu-repo/semantics/article
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Combining the reasoned action approach and habit formation to reduce sitting time in classrooms: Outcome and process evaluation of the Let's Move It teacher intervention
(Elsevier BV, 2018)Creating active classroom environments and reducing excessive student sitting requires changes in teachers' behaviours. This study examines a teacher training intervention, which aimed to increase the extent to which ...Tieteelliset aikakauslehtiartikkelit
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Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
(The American Society for Pharmacology and Experimental Therapeutics, 2022)
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Common data elements and data management: Remedy to cure underpowered preclinical studies
(Elsevier BV, 2016)Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization ...info:eu-repo/semantics/article
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Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia
(BioMed Central, 2016)Background Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference ...info:eu-repo/semantics/article
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Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers
(Oxford University Press (OUP), 2017)Study Objectives: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift ...info:eu-repo/semantics/article
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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
(Public Library of Science (PLoS), 2017)Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based ...info:eu-repo/semantics/article
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Comorbid opioid use is undertreated among forensic patients with schizophrenia
(Springer Nature America, Inc, 2018)Background Substance use disorders are associated with poorer clinical outcomes in patients with schizophrenia. There is no specific treatment for amphetamine or cannabis use disorder, but methadone and buprenorphine are ...Tieteelliset aikakauslehtiartikkelit
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Comparative Effectiveness of Antipsychotic Drugs for Rehospitalization in Schizophrenia-A Nationwide Study With 20-Year Follow-up
(Oxford University Press (OUP), 2018)Very little is known about the comparative long-term effectiveness of novel antipsychotics in relapse prevention, especially in first-episode schizophrenia. Nationwide data from Finnish health care registers were gathered ...info:eu-repo/semantics/article
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Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom
(Springer Nature, 2018)The dopaminergic hypothesis of schizophrenia is the main concept explaining the direct reasons of schizophrenia and the effectiveness of current antipsychotics. All antipsychotics present on the market are potent dopamine ...Tieteelliset aikakauslehtiartikkelit
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Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties
(Elsevier BV, 2019)There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression ...Tieteelliset aikakauslehtiartikkelit
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Comparison between twin-screw and high-shear granulation - The effect of filler and active pharmaceutical ingredient on the granule and tablet properties
(Elsevier BV, 2020)The aim of the study was to compare continuous twin-screw granulation (TSG) with batch-wise high-shear granulation (HSG). Two different formulations containing either microcrystalline cellulose (MCC) and mannitol or MCC ...Tieteelliset aikakauslehtiartikkelit
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Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study
(JMIR Publications Inc., 2021)Background: Clinical trials have shown that type 2 diabetes (T2D) is preventable through lifestyle interventions targeting high-risk people. Nevertheless, large-scale implementation of risk identification followed by ...Tieteelliset aikakauslehtiartikkelit
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Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study
(Springer Nature, 2016)Osteoarthritis (OA) is a common degenerative musculoskeletal disease highly prevalent in aging societies worldwide. Traditionally, knee OA is diagnosed using conventional radiography. However, structural changes of articular ...info:eu-repo/semantics/article
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Comparison of efficiency and function of VEGF adenovirus vectors in endothelial cells for gene therapy of placental insufficiency
(Mary Ann Liebert Inc, 2020)Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency ...Tieteelliset aikakauslehtiartikkelit
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Comparison of Expert Opinion, Majority Rule, and a Clinical Prediction Rule to Estimate Distal Radius Malalignment
(Ovid Technologies (Wolters Kluwer Health), 2017)Objectives: To investigate the ability of individual surgeons (expert opinion [EO]) to predict distal radius fracture healing above a threshold malalignment compared with the majority prediction of the group of surgeons ...info:eu-repo/semantics/article
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Comparison of feature representations in MRI-based MCI-to-AD conversion prediction
(Elsevier BV, 2018)Alzheimer's disease (AD) is a progressive neurological disorder in which the death of brain cells causes memory loss and cognitive decline. The identification of at-risk subjects yet showing no dementia symptoms but who ...Tieteelliset aikakauslehtiartikkelit