Browsing Terveystieteiden tiedekunta by Title

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    • Current Concepts and Treatments of Schizophrenia 

      Stepnicki, Piotr; Kondej, Magda; Kaczor, Agnieszka A (MDPI AG, 2018)
      Schizophrenia is a debilitating mental illness which involves three groups of symptoms, i.e., positive, negative and cognitive, and has major public health implications. According to various sources, it affects up to 1% ...
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    • Current Situation and Challenges in Vitreous Substitutes 

      Mondelo-García, C; Bandín-Vilar, E; García-Quintanilla, L; Castro-Balado, A; Del Amo, EM; Gil-Martínez, M; Blanco-Teijeiro, MJ; González-Barcia, M; Zarra-Ferro, I; Fernández-Ferreiro, A; Otero-Espinar, FJ (Wiley, 2021)
      Vitreo-retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo-retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous ...
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    • Curricula Challenges and Informatics Competencies for Nurse Educators 

      Kinnunen U-M; Rajalahti E; Cummings E; Borycki EM (IOS Press, 2017)
      Nursing informatics competencies are fundamental to nursing practice in all areas of nursing work, including direct patient care, administration and education. The recent activity relating to the development of nursing ...
      info:eu-repo/semantics/bookPart

    • Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells 

      Lindqvist, Julia; Imanishi, Susumu Y.; Torvaldson, Elin; Malinen, Marjo; Remes, Mika; Örn, Fanny; Palvimo, Jorma J.; Eriksson, John E. (American Society for Cell Biology (ASCB), 2015)
      Contrary to cell cycle–associated cyclin-dependent kinases, CDK5 is best known for its regulation of signaling processes in differentiated cells and its destructive activation in Alzheimer's disease. Recently, CDK5 has ...
      info:eu-repo/semantics/article

    • Cyclodextrin-based organic radical contrast agents for in vivo imaging of glioma 

      Melone, Lucio; Bach, Alice; Lamura, Gianrico; Canepa, Fabio; Nivajärvi, Riikka; Olsson, Venla; Kettunen, Mikko (Wiley, 2020)
      Cyclodextrins (CDs), a class of cyclic oligosaccharides formed by α‐(1,4) linked glucopyranose units, were functionalized with (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) radicals to prepare water soluble supramolecular ...
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    • Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors 

      von Ossowski L; Li LL; Möykkynen T; Coleman SK; Courtney MJ; Keinänen K (Public Library of Science (PLoS), 2017)
      Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the role of a reactive cysteine residue, Cys-893, in the cytosolic ...
      info:eu-repo/semantics/article

    • Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach 

      Kokki Merja; Pesonen Maija; Vehviläinen Piia; Litmala Outi; Pasanen Markku; Kokki Hannu (Springer, 2016)
      Background and Objectives Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater ...
      info:eu-repo/semantics/article

    • DAPI (4’,6-diamidino-2-phenylindole) Stains Compact Amyloid Plaques 

      Mabrouk, Rana; Gotkiewicz, Maria; Rauramaa, Tuomas; Tanila, Heikki (IOS Press., 2022)
      DAPI is conventionally used as a nuclear stain for cells in culture or tissue. Here we demonstrate that it binds specifically to the β-sheet core of amyloid-β plaques but not diffuse amyloid-β at the plaque periphery. The ...

    • Dark chocolate and reduced snack consumption in mildly hypertensive adults: an intervention study 

      Koli, Raika; Köhler, Klaus; Tonteri, Elina; Peltonen, Juha; Tikkanen, Heikki; Fogelholm, Mikael (BioMed Central, 2015)
      Background Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate ...
      info:eu-repo/semantics/article

    • Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase 

      Yanvarev DV; Korovina AN; Usanov NN; Khomich OA; Vepsäläinen Jouko; Puljula Elina; Kukhanova MK; Kochetkov SN (Elsevier Inc., 2016)
      Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes, IN [1] and RT [2]. Herein, we present chemical synthesis of ...
      info:eu-repo/semantics/article

    • Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier 

      Tolonen, Antti; Rhodius-Meester, Hanneke F M; Bruun, Marie; Koikkalainen, Juha; Barkhof, Frederik; Lemstra, Afina W; Koene, Teddy; Scheltens, Philip; Teunissen, Charlotte E; Tong, Tong; Guerrero, Ricardo; Schuh, Andreas; Ledig, Christian; Baroni, Marta; Rueckert, Daniel; Soininen, Hilkka; Remes, Anne M; Waldemar, Gunhild; Hasselbalch, Steen G; Mecocci, Patrizia; van der Flier, Wiesje M; Lotjönen, Jyrki (Frontiers Media SA, 2018)
      Clinical decision support systems (CDSSs) hold potential for the differential diagnosis of neurodegenerative diseases. We developed a novel CDSS, the PredictND tool, designed for differential diagnosis of different types ...
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    • Data-Driven Identification of Long-Term Glycemia Clusters and Their Individualized Predictors in Finnish Patients with Type 2 Diabetes 

      Lavikainen, Piia; Chandra, Gunjan; Siirtola, Pekka; Tamminen, Satu; Ihalapathirana, Anusha T; Röning, Juha; Laatikainen, Tiina; Martikainen, Janne (Dove Press Ltd, 2023)
      Purpose: To gain an understanding of the heterogeneous group of type 2 diabetes (T2D) patients, we aimed to identify patients with the homogenous long-term HbA1c trajectories and to predict the trajectory membership for ...

    • Data-driven long-term glycaemic control trajectories and their associated health and economic outcomes in Finnish patients with incident type 2 diabetes 

      Lavikainen, Piia; Aarnio, Emma; Linna, Miika; Jalkanen, Kari; Tirkkonen, Hilkka; Rautiainen, Päivi; Laatikainen, Tiina; Martikainen, Janne (Public Library of Science, 2022)
      Background Treatments should be customized to patients to improve patients’ health outcomes and maximize the treatment benefits. We aimed to identify meaningful data-driven trajectories of incident type 2 diabetes patients ...

    • Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma 

      Poukka, M; Bykachev, A; Siiskonen, H; Tyynelä-Korhonen, K; Auvinen, P; Pasonen-Seppänen, S; Sironen, R (BioMed Central Ltd., 2016)
      Background Hyaluronan is a large extracellular matrix molecule involved in several biological processes such as proliferation, migration and invasion. In many cancers, hyaluronan synthesis is altered, which implicates ...
      info:eu-repo/semantics/article

    • Decreased plasma C-reactive protein levels in APOE E 4 allele carriers 

      Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko (Wiley, 2018)
      Objective Apolipoprotein E (APOE) ε4 allele is a well‐established risk factor in Alzheimer's disease (AD). Here, we assessed the effects of APOE polymorphism on cardiovascular, metabolic, and inflammation‐related parameters ...
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    • DeepCDA: Deep Cross-Domain Compound-Protein Affinity Prediction through LSTM and Convolutional Neural Networks 

      Abbasi, Karim; Razzaghi, Parvin; Poso, Antti; Amanlou, Massoud; Ghasemi, Jahan B; Masoudi-Nejad, Ali (Oxford University Press (OUP), 2020)
      Motivation An essential part of drug discovery is the accurate prediction of the binding affinity of new compound–protein pairs. Most of the standard computational methods assume that compounds or proteins of the test ...
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    • Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility 

      Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A (Elsevier BV, 2019)
      Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the cerebral cortex and tissue remodeling ...
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    • Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease 

      Andersen, Jens V; Christensen, Sofie K; Westi, Emil W; Diaz-delCastillo, Marta; Tanila, Heikki; Schousboe, Arne; Aldana, Blanca I; Waagepetersen, Helle S (Elsevier BV, 2021)
      Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid ...
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    • Defining Terms Used for Animals Working in Support Roles for People with Support Needs 

      Howell, Tiffani J; Nieforth, Leanne; Thomas-Pino, Clare; Samet, Lauren; Agbonika, Sunday; Cuevas-Pavincich, Francisca; Fry, Nina Ekholm; Hill, Kristine; Jegatheesan, Brinda; Kakinuma, Miki; MacNamara, Maureen; Mattila-Rautiainen, Sanna; Perry, Andy; Tardif-Williams, Christine Y; Walsh, Elizabeth Ann; Winkle, Melissa; Yamamoto, Mariko; Yerbury, Rachel; Rawat, Vijay; Alm, Kathy; et al (MDPI, 2022)
      The nomenclature used to describe animals working in roles supporting people can be confusing. The same term may be used to describe different roles, or two terms may mean the same thing. This confusion is evident among ...

    • Defining the risk factors for acute, subacute and chronic cough: a cross-sectional study in a Finnish adult employee population . 

      Lätti, Anne M; Pekkanen, Juha; Koskela, Heikki O (BMJ, 2018)
      Objectives Chronic cough is linked to various long-standing risk factors like asthma, chronic rhinitis and oesophageal reflux disease. On the contrary, acute and subacute cough are usually considered to be caused by acute ...
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