Browsing Terveystieteiden tiedekunta by Title

Now showing items 563-582 of 1735

    • ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease 

      Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu (Springer Science and Business Media LLC, 2020)
      The endoplasmic reticulum (ER) contains stress sensors which recognize the accumulation of unfolded proteins within the lumen of ER, and subsequently these transducers stimulate the unfolded protein response (UPR). The ER ...
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    • Eristys päivähoidosta infektion vuoksi 

      Peltola, Ville; Renko, Marjo (Suomalainen lääkäriseura Duodecim, 2021)
      Pienet lapset sairastavat paljon tarttuvia tauteja, ja päiväkodissa kontaktit ovat tiiviitä. Lapsen poissaolo päivähoidosta määräytyy ennen kaikkea hänen vointinsa mukaan: sairas lapsi hoidetaan kotona, ja hoitoon voi ...
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    • ERN-verkostot kokoavat harvinaissairauksien osaajat yhteen 

      Lempainen, Johanna; Kälviäinen, Reetta; Heiskanen-Kosma, Tarja (Suomen lääkäriliitto, 2023)
      • EU:n alaisuuteen on vuodesta 2017 alkaen perustettu yhteensä 24 harvinaissairauksien ERN-osaamisverkostoa. Kaikissa on vähintään yksi suomalainen jäsenkeskus. • Verkostot auttavat tavoittamaan asiantuntijoita koko EU:ssa. ...

    • ESGCT 2017 in Berlin: Clear Steps Forward 

      Ylä-Herttuala S (Elsevier BV, 2017)
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    • Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling 

      Zhou, Zhenqi; Moore, Timothy M; Drew, Brian G; Ribas, Vicent; Wanagat, Jonathan; Civelek, Mete; Segawa, Mayuko; Wolf, Dane M; Norheim, Frode; Seldin, Marcus M; Strumwasser, Alexander R; Whitney, Kate A; Lester, Ellen; Reddish, Britany R; Vergnes, Laurent; Reue, Karen; Rajbhandari, Prashant; Tontonoz, Peter; Lee, Jason; Mahata, Sushil K [et al incl. Laakso, Markku] (American Association for the Advancement of Science (AAAS), 2020)
      Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose ...
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    • Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation 

      Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; Daley, F; Blows, F; Benitez, J; Milne, RL; Brenner, H; Stegmaier, C; Mannermaa, A; Rudolph, A; Sinn, P; Couch, FJ; Devilee, P; Tollenaar, RA; Seynaeve, C; Figueroa, J; Lissowska, J; et al. (Wiley, 2018)
      Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ...
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    • Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: A population-based study 

      Sokka Arja; Olsen Päivi; Kirjavainen Jarkko; Harju Maijakaisa; Keski-Nisula Leea; Räisänen Sari; Heinonen Seppo; Kälviäinen Reetta (Wiley-Blackwell, 2017)
      Objective To evaluate the prevalence of various etiologies of epilepsies and epilepsy syndromes and to estimate cognitive function in cases of childhood-onset epilepsy. Methods A population-based retrospective registry ...
      info:eu-repo/semantics/article

    • European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) 

      Egea J; Fabregat I; Frapart YM; Ghezzi P; Görlach A; Kietzmann T; Kubaichuk K; Knaus UG; Lopez MG; Olaso-Gonzalez G; Petry A; Schulz R1; Vina J; Winyard P; Abbas K; Ademowo OS; Afonso CB; Andreadou I; Antelmann H; Antunes F; Aslan M; Bachschmid MM; Barbosa RM; Belousov V; Berndt C; Bernlohr D; Bertrán E; Bindoli A; Bottari SP; Brito PM; Carrara G; Casas AI; Chatzi A; Chondrogianni N; Conrad M; Cooke MS; Costa JG; Cuadrado A; My-Chan Dang P; De Smet B; Debelec-Butuner B; Dias IHK; Dunn JD; Edson AJ; Giniatullin R; et al (Elsevier BV, 2017)
      The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different ...
      info:eu-repo/semantics/article

    • European health examination surveys - a tool for collecting objective information about the health of the population 

      Tolonen, Hanna; Koponen, Päivikki; Al-kerwi, Ala'a; Capkova, Nada; Giampaoli, Simona; Mindell, Jennifer; Paalanen, Laura; Ruiz-Castell, Maria; Trichopoulou, Antonia; Kuulasmaa, Kari; the EHES Network incl. Diem, Günter; van der Heyden, Johan; Dimitrov, Plamen; Lappée, Marcel; Kubinova, Ruzena; Jørgensen, Torben; Linneberg, Allan; Grønbæk, Morten; Eriksen, Louise; Laatikainen, Tiina (Springer Nature, 2018)
      Background Representative and reliable data on health and health determinants of the population and population sub-groups are needed for evidence-informed policy making; planning and evaluation of prevention programmes; ...
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    • Evaluating combinations of diagnostic tests to discriminate different dementia types 

      Bruun, Marie; Rhodius-Meester, Hanneke FM; Koikkalainen, Juha; Baroni, Marta; Gjerum, Le; Lemstra, Afina W; Barkhof, Frederik; Remes, Anne M; Urhemaa, Timo; Tolonen, Antti; Rueckert, Daniel; van Gils, Mark; Frederiksen, Kristian S; Waldemar, Gunhild; Scheltens, Philip; Mecocci, Patrizia; Soininen, Hilkka; Lötjönen, Jyrki; Hasselbalch, Steen G; van der Flier, Wiesje M (Elsevier BV, 2018)
      Introduction We studied, using a data-driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia. Methods In this multicenter study, we included 356 patients ...
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    • Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells 

      Singha, Prosanta; Mäklin, Kiira; Vihavainen, Taina; Laitinen, Tuomo; Nevalainen, Tapio; Patil, Mahadeo; Tonduru, Arun; Poso, Antti; Laitinen, Jarmo; Savinainen, Juha (Elsevier BV, 2020)
      De novo synthesis of fatty acids is essential to maintain intensive proliferation of cancer cells. Unlike normal cells that utilize food-derived circulating lipids for their fuel, cancer cells rely on heightened lipogenesis ...
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    • Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat 

      Paasonen, Ekaterina; Paasonen, Jaakko; Lehto, Lauri J; Pirttimäki, Tiina; Laakso, Hanne; Wu, Lin; Ma, Jun; Idiyatullin, Djaudat; Tanila, Heikki; Mangia, Silvia; Michaeli, Shalom; Gröhn, Olli (John Wiley & Sons, Inc., 2022)
      Purpose To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation ...

    • Exercise heart rate reserve and recovery as risk factors for sudden cardiac death 

      Kurl, Sudhir; Jae, Sae Young; Voutilainen, Ari; Hagnäs, Magnus; Laukkanen, Jari A. (Elsevier BV, 2021)
      Background Little is known if heart rate responses during and after exercise test may be associated with the risk of sudden cardiac death (SCD). Our aim was to determine if exercise heart rate reserve and recovery, providing ...
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    • Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR's EXTRA) 

      Komulainen, Pirjo; Tuomilehto, Jaakko; Savonen, Kai; Männikkö, Reija; Hassinen, Maija; Lakka, Timo A; Hänninen, Tuomo; Kiviniemi, Vesa; Jacobs, David R; Kivipelto, Miia; Rauramaa, Rainer (Oxford University Press (OUP), 2021)
      Background Evidence for the effects of exercise and dietary interventions on cognition from long-term randomized controlled trials (RCTs) in large general populations remains insufficient. Objective The objective of ...
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    • Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use 

      Brazel, DM; Jiang, Y; Hughey, JM; Turcot, V; Zhan, X; Gong, J; Batini, C; Weissenkampen, JD; Liu, M; Barnes, DR; Bertelsen, S; Chou, YL; Erzurumluoglu, AM; Faul, JD; Haessler, J; Hammerschlag, AR; Hsu, C; Kapoor, M; Lai, D; Le, N; et al. (Incl. Laakso, Markku) (Elsevier BV, 2019)
      Background Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome ...
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    • Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process 

      Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu (Elsevier BV, 2020)
      Exosomes represent an evolutionarily conserved signaling pathway which can act as an alarming mechanism in responses to diverse stresses, e.g. chronic inflammation activates the budding of exosomal vesicles in both immune ...
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    • Exosomes as secondary inductive signals involved in kidney organogenesis 

      Krause, M; Rak-Raszewska, A; Naillat, F; Saarela, U; Schmidt, C; Ronkainen, VP; Bart, G; Ylä-Herttuala, S; Vainio, SJ (Informa UK Limited, 2018)
      The subfraction of extracellular vesicles, called exosomes, transfers biological molecular information not only between cells but also between tissues and organs as nanolevel signals. Owing to their unique properties such ...
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    • Experiential Thinking in Creationism - A Textual Analysis 

      Nieminen, Petteri; Ryökäs, Esko; Mustonen, Anne-Mari (PLOS, 2015)
      Creationism is a religiously motivated worldview in denial of biological evolution that has been very resistant to change. We performed a textual analysis by examining creationist and pro-evolutionary texts for aspects of ...
      info:eu-repo/semantics/article

    • Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure 

      Marques FZ; Prestes PR; Byars SG; Ritchie SC; Würtz P; Patel SK; Booth SA; Rana I; Minoda Y; Berzins SP; Curl CL; Bell JR; Wai B; Srivastava PM; Kangas AJ; Soininen P; Ruohonen S; Kähönen M; Lehtimäki T; Raitoharju E et al. (Ovid Technologies (Wolters Kluwer Health), 2017)
      Background Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin‐2 (LCN2/NGAL), is elevated in certain forms of cardiac hypertrophy and ...
      info:eu-repo/semantics/article

    • Experimental Endometriosis: Review of the Literature Through a Century and the Iranian Experience 

      Alborzi, S; Azimirad, A; Azimirad, M (Academy of Medical Sciences of the I.R. Iran, 2018)
      Although endometriosis is not a newly discovered disease, it has still remained enigmatic. Understanding the pathophysiology of this disease is still one of the challenges of gynecology and reproductive medicine. Therefore, ...
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