Browsing Terveystieteiden tiedekunta by Title
Now showing items 1305-1324 of 1735
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Production and characterization of glibenclamide incorporated PLA filaments for 3D printing by fused deposition modeling
(Elsevier B.V., 2022)In this work a soaking method for incorporating glibenclamide (GBC), a poorly soluble API, into prefabricated polylactic acid (PLA) filaments intended for 3D printing by fused deposition modeling (FDM) was developed and ...
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Profiling of Endogenous and Gut Microbial Metabolites to Indicate Metabotype-Specific Dietary Responses: A Systematic Review
(Oxford University Press (OUP), 2020)Upon dietary exposure, the endogenous metabolism responds to the diet-derived nutrients and bioactive compounds, such as phytochemicals. However, the responses vary remarkably due to the interplay with other dietary ...Tieteelliset aikakauslehtiartikkelit
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Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines
(Elsevier, 2022)Alterations in epigenetic marking, due to changes in expression or activity of epigenetic regulators, may affect cancer development and progression and thus, targeting epigenetic regulators provides potential avenues for ...
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Prognosis of ovarian cancer in women with type 2 diabetes using metformin and other forms of antidiabetic medication or statins: a retrospective cohort study
(Springer Nature, 2018)Background Ovarian cancer is one of the most lethal cancers and women with type 2 diabetes (T2D) have even poorer survival from it. We assessed the prognosis of ovarian cancer in women with type 2 diabetes treated with ...Tieteelliset aikakauslehtiartikkelit
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Prognostic and predictive role of spatially positioned tumour infiltrating lymphocytes in metastatic HER2 positive breast cancer treated with trastuzumab
(Springer Nature, 2017)Disease outcomes of HER2+ breast cancers have dramatically changed after targeted therapies, such as trastuzumab, came to clinical practice but predictive factors for trastuzumab sensitivity and resistance are frequently ...info:eu-repo/semantics/article
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Prognostic Value of Preoperative Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Epithelial Ovarian Cancer
(Elsevier BV, 2019)Objectives To investigate whether semi-quantitative and pharmacokinetic perfusion dynamic contrast-enhanced (DCE) parameters are associated with traditional prognostic factors and can predict clinical outcome in ovarian ...Tieteelliset aikakauslehtiartikkelit
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Progressive age-dependent motor impairment in human tau P301S overexpressing mice
(Elsevier BV, 2019)This study assessed the development of motor deficits in female hTau.P301S transgenic mice from 1.5 to 5.5 months of age. The test battery included clasping reflex, grid hanging, Rotarod test, spontaneous explorative ...Tieteelliset aikakauslehtiartikkelit
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Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
(Nature Publishing Group, 2016)Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, ...info:eu-repo/semantics/article
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Promoting safe walking among older people: the effects of a physical and cognitive training intervention vs. physical training alone on mobility and falls among older community-dwelling men and women (the PASSWORD study): design and methods of a randomized controlled trial
(Springer Nature America, Inc, 2018)Background Safe and stable walking is a complex process involving the interaction of neuromuscular, sensory and cognitive functions. As physical and cognitive functions deteriorate with ageing, training of both functions ...Tieteelliset aikakauslehtiartikkelit
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Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes
(Public Library of Science (PLoS), 2018)Meta-analysis of genetic association studies increases sample size and the power for mapping complex traits. Existing methods are mostly developed for datasets without missing values, i.e. the summary association statistics ...Tieteelliset aikakauslehtiartikkelit
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Prospective association between tobacco smoking and death by suicide: a competing risks hazard analysis in a large twin cohort with 35-year follow-up
(Cambridge University Press (CUP), 2017)The relationship between smoking and suicide remains controversial. A total of 16 282 twin pairs born before 1958 in Finland and alive in 1974 were queried with detailed health and smoking questionnaires in 1975 and 1981, ...info:eu-repo/semantics/article
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Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells
(Elsevier BV, 2019)Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. However, their relevance for investigations of drug-drug and drug-organic anion (e.g., ...Tieteelliset aikakauslehtiartikkelit
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Protein Phosphatase 1 Regulatory Subunit 3B Gene Variation Protects Against Hepatic Fat Accumulation and Fibrosis in Individuals at High Risk of Nonalcoholic Fatty Liver Disease
(Wiley, 2018)Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver damage and has a strong genetic component. The rs4841132 G>A variant, modulating the expression of protein phosphatase 1 regulatory subunit 3B (PPP1R3B), ...Tieteelliset aikakauslehtiartikkelit
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Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma
(Elsevier BV, 2018)Background We studied the expression of some major proteins involved in cell-cycle regulation and DNA repair, the roles of which are not well known in pancreatic ductal adenocarcinoma (PDAC), but which have a significant ...Tieteelliset aikakauslehtiartikkelit
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Protocol for a systematic review and meta-analysis assessing the effectiveness of deprescribing in falls prevention in older people
(BMJ, 2021)Introduction One of the known risk factors for fall incidents is the use of specific medications, fall-risk-increasing drugs (FRIDs). However, to date, there is uncertainty related to the effectiveness of deprescribing ...Tieteelliset aikakauslehtiartikkelit
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Proton pump inhibitor use and risk of hip fractures among community-dwelling persons with Alzheimer's disease-a nested case-control study
(Wiley-Blackwell, 2018)Background Hip fractures are a major health concern among older persons with Alzheimer's disease, who usually use many concomitant drugs for several diseases. Evidence of the association between proton pump inhibitor use ...Tieteelliset aikakauslehtiartikkelit
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Provoking an end-to-end continuous direct compression line with raw materials prone to segregation
(Elsevier BV, 2017)Continuous manufacturing of solid oral dosage forms is promising for increasing the efficiency and quality of pharmaceutical production and products. In this study a whole train continuous direct compression (CDC) line has ...info:eu-repo/semantics/article
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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
(Elsevier BV, 2017)Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there are no efficient therapies for AD. Most ...info:eu-repo/semantics/article
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Psychotropic Drug-Associated Pneumonia in Older Adults
(Springer Science and Business Media LLC, 2020)The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-related drugs, and antidepressants) is common, with a prevalence estimates range of 19–29% among community dwelling older adults. These drugs ...Tieteelliset aikakauslehtiartikkelit
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Psychotropic medication after intensive care unit treated pediatric traumatic brain injury
(Elsevier BV, 2020)Background Our aim was to assess the occurrence and risk factors for psychotropic medication use after pediatric traumatic brain injury treated in the intensive care unit. Methods We combined data from the Finnish ...Tieteelliset aikakauslehtiartikkelit